使用[镓]PSMA I&T检测前列腺癌生化复发患者中PET/CT的检出率，并与[镓]PSMA HBED-CC的已发表数据进行比较。
Detection rate of PET/CT in patients with biochemical relapse of prostate cancer using [Ga]PSMA I&T and comparison with published data of [Ga]PSMA HBED-CC.
作者信息
Berliner Christoph, Tienken Milena, Frenzel Thorsten, Kobayashi Yuske, Helberg Annabelle, Kirchner Uve, Klutmann Susanne, Beyersdorff Dirk, Budäus Lars, Wester Hans-Jürgen, Mester Janos, Bannas Peter
机构信息
Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Ambulatory Center, Department for Radiation Oncology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
出版信息
Eur J Nucl Med Mol Imaging. 2017 Apr;44(4):670-677. doi: 10.1007/s00259-016-3572-5. Epub 2016 Nov 28.
PURPOSE
To determine the detection rate of PET/CT in biochemical relapse of prostate cancer using [Ga]PSMA I&T and to compare it with published detection rates of [Ga]PSMA HBED-CC.
METHODS
We performed a retrospective analysis in 83 consecutive patients with documented biochemical relapse after prostatectomy. All patients underwent whole body [Ga]PSMA I&T PET/CT. PET/CT images were evaluated for presence of local recurrence, lymph node metastases, and distant metastases. Proportions of positive PET/CT results were calculated for six subgroups with increasing prostate specific antigen (PSA) levels (<0.5 ng/mL, 0.5 to <1.0 ng/mL, 1.0 to <2.0 ng/mL, 2.0 to <5.0 ng/mL, 5.0 to <10.0, ≥10.0 ng/mL). Detection rates of [Ga]PSMA I&T were statistically compared with published detection rates of [Ga]PSMA HBED-CC using exact Fisher's test.
RESULTS
Median PSA was 0.81 (range: 0.01 - 128) ng/mL. In 58/83 patients (70 %) at least one [Ga]PSMA I&T positive lesion was detected. Local recurrent cancer was present in 18 patients (22 %), lymph node metastases in 29 patients (35 %), and distant metastases in 15 patients (18 %). The tumor detection rate was positively correlated with PSA levels, resulting in detection rates of 52 % (<0.5 ng/mL), 55 % (0.5 to <1.0 ng/mL), 70 % (1.0 to <2.0 ng/mL), 93 % (2.0 to <5.0 ng/mL), 100 % (5.0 to <10.0 ng/mL), and 100 % (≥10.0 ng/mL). There was no significant difference between the detection rate of [Ga]PSMA I&T and published detection rates of [Ga]PSMA HBED-CC (all p>0.05).
CONCLUSIONS
[Ga]PSMA I&T PET/CT has high detection rates of recurrent prostate cancer that are comparable to [Ga]PSMA HBED-CC.
目的
使用[镓]PSMA I&T确定PET/CT在前列腺癌生化复发中的检出率，并将其与已发表的[镓]PSMA HBED-CC的检出率进行比较。
方法
我们对83例前列腺切除术后有生化复发记录的连续患者进行了回顾性分析。所有患者均接受了全身[镓]PSMA I&T PET/CT检查。对PET/CT图像评估局部复发、淋巴结转移和远处转移的情况。计算了六个前列腺特异性抗原（PSA）水平升高亚组（<0.5 ng/mL、0.5至<1.0 ng/mL、1.0至<2.0 ng/mL、2.0至<5.0 ng/mL、5.0至<10.0、≥10.0 ng/mL）中PET/CT阳性结果的比例。使用精确Fisher检验将[镓]PSMA I&T的检出率与已发表的[镓]PSMA HBED-CC的检出率进行统计学比较。
结果
PSA中位数为0.81（范围：0.01 - 128）ng/mL。在83例患者中的58例（70%）中检测到至少一个[镓]PSMA I&T阳性病变。18例患者（22%）存在局部复发性癌症，29例患者（35%）有淋巴结转移，15例患者（18%）有远处转移。肿瘤检出率与PSA水平呈正相关，<0.5 ng/mL时检出率为52%，0.5至<1.0 ng/mL时为55%，1.0至<2.0 ng/mL时为70%，2.0至<5.0 ng/mL时为93%，5.0至<10.0 ng/mL时为100%，≥10.0 ng/mL时为100%。[镓]PSMA I&T的检出率与已发表的[镓]PSMA HBED-CC的检出率之间无显著差异（所有p>0.05）。
结论
[镓]PSMA I&T PET/CT对复发性前列腺癌的检出率较高，与[镓]PSMA HBED-CC相当。
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