慢性酒精滥用中的胎盘酒精代谢

Placental alcohol metabolism in chronic alcohol abuse.

作者信息

Andersson S, Halmesmäki E, Koivusalo M, Lapatto R, Ylikorkala O

机构信息

Children's Hospital, University Central Hospital, Helsinki, Finland.

出版信息

Biol Neonate. 1989;56(2):90-3. doi: 10.1159/000243107.

DOI:10.1159/000243107

PMID:2790089

Abstract

The activities of aldehyde dehydrogenase (ALDH; EC 1.2.1.3) and alcohol dehydrogenase (ADH; EC 1.1.1.1) were measured in term placentas of 13 alcoholic women and 16 matched controls. With acetaldehyde 8 mmol/l as substrate, the ALDH activity was 29.1 +/- 12.2 and 34.4 +/- 15.3 mU/g of wet weight (mean +/- SD; p greater than 0.4) for alcoholics and controls, respectively. With 50 mumol of acetaldehyde, ALDH activity was undetectable in both groups. No ADH activity could be detected in the placentas. The weights of placentas and newborns were significantly lower in the alcoholic group (placentas: 526 +/- 116 vs. 653 +/- 77 g, p less than 0.005; newborns 2,878 +/- 417 vs. 3,595 +/- 346 g, p less than 0.001). The results suggest that in chronic alcohol abuse, the placenta plays a negligible role in the metabolism of ethanol and acetaldehyde.

摘要

在13名酗酒女性和16名配对对照者的足月胎盘中测量了醛脱氢酶（ALDH；EC 1.2.1.3）和乙醇脱氢酶（ADH；EC 1.1.1.1）的活性。以8 mmol/l乙醛为底物时，酗酒者和对照者的ALDH活性分别为29.1±12.2和34.4±15.3 mU/g湿重（平均值±标准差；p>0.4）。以50 μmol乙醛为底物时，两组均未检测到ALDH活性。在胎盘中未检测到ADH活性。酗酒组胎盘和新生儿的重量显著更低（胎盘：526±116 vs. 653±77 g，p<0.005；新生儿：2878±417 vs. 3595±346 g，p<0.001）。结果表明，在慢性酒精滥用中，胎盘在乙醇和乙醛代谢中起的作用可忽略不计。