Kumar K Shiva, Bhaskar Boyapally, Ramulu Meesa Siddi, Kumar N Praveen, Ashfaq Mohd Ashraf, Pal Manojit
Department of Chemistry, Osmania University, Hyderabad-500 007, India.
Dr Reddy's Institute of Life Sciences, Hyderabad Central University, Campus, Gachibowli, Hyderabad-500 046, India.
Org Biomol Chem. 2016 Dec 20;15(1):82-87. doi: 10.1039/c6ob02340a.
TFA alone was found to be remarkably effective for the intramolecular hydroarylation (IMHA) of alkynes when employed as a solvent in the cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines. This simple and metal free cyclization method afforded a range of indolophenazines as new and potential cytotoxic agents. The use of excess TFA was found to be crucial for the success of this reaction.
当在3-炔基取代的2-(吲哚-3-基)喹喔啉的环化反应中用作溶剂时，发现仅三氟乙酸（TFA）对炔烃的分子内氢芳基化（IMHA）非常有效。这种简单的无金属环化方法提供了一系列吲哚吩嗪作为新型潜在细胞毒性剂。发现使用过量的三氟乙酸对该反应的成功至关重要。
Zotero 插件