炎症引起的铁调素上调独立于激活素B介导的Smad1/5/8信号传导。 - Suppr

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

作者信息

Besson-Fournier Céline, Gineste Aurélie, Latour Chloé, Gourbeyre Ophélie, Meynard Delphine, Martin Patricia, Oswald Eric, Coppin Hélène, Roth Marie-Paule

机构信息

IRSD (Institut de Recherche en Santé Digistive), Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France; and.

Laboratoire de Bactériologie-Hygiène, CHU Toulouse, Toulouse, France.

出版信息

Blood. 2017 Jan 26;129(4):533-536. doi: 10.1182/blood-2016-10-748541. Epub 2016 Nov 30.

DOI:10.1182/blood-2016-10-748541

PMID:27903526

Abstract

摘要

相似文献

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

Blood. 2017 Jan 26;129(4):533-536. doi: 10.1182/blood-2016-10-748541. Epub 2016 Nov 30.

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.

Blood. 2012 Jul 12;120(2):431-9. doi: 10.1182/blood-2012-02-411470. Epub 2012 May 18.

Regulation of hepcidin expression by inflammation-induced activin B.

Sci Rep. 2016 Dec 6;6:38702. doi: 10.1038/srep38702.

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.

Endocrinology. 2016 Mar;157(3):1146-62. doi: 10.1210/en.2015-1747. Epub 2016 Jan 6.

Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.

J Am Soc Nephrol. 2016 Mar;27(3):835-46. doi: 10.1681/ASN.2014101035. Epub 2015 Aug 20.

Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation.

Haematologica. 2015 Feb;100(2):e68-71. doi: 10.3324/haematol.2014.111484. Epub 2014 Oct 17.

Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling.

Blood. 2018 Oct 25;132(17):1829-1841. doi: 10.1182/blood-2018-03-841197. Epub 2018 Sep 13.

Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice.

Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G132-9. doi: 10.1152/ajpgi.00256.2013. Epub 2013 Nov 27.

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

Hepatology. 2009 Dec;50(6):1992-2000. doi: 10.1002/hep.23198.

Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice.

Am J Hematol. 2019 Feb;94(2):240-248. doi: 10.1002/ajh.25366. Epub 2018 Dec 10.

引用本文的文献

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Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice.

Front Cell Infect Microbiol. 2021 Jul 23;11:705087. doi: 10.3389/fcimb.2021.705087. eCollection 2021.

Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders.

Br J Haematol. 2021 Jun;193(5):882-893. doi: 10.1111/bjh.17252. Epub 2020 Dec 14.

Bone morphogenic proteins in iron homeostasis.

Bone. 2020 Sep;138:115495. doi: 10.1016/j.bone.2020.115495. Epub 2020 Jun 23.

Extrahepatic hepcidin production: The intriguing outcomes of recent years.

World J Clin Cases. 2019 Aug 6;7(15):1926-1936. doi: 10.12998/wjcc.v7.i15.1926.

Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.

Hepatology. 2019 Dec;70(6):1986-2002. doi: 10.1002/hep.30780. Epub 2019 Aug 13.

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Pharmaceuticals (Basel). 2019 Apr 16;12(2):59. doi: 10.3390/ph12020059.

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Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

作者信息

Besson-Fournier Céline, Gineste Aurélie, Latour Chloé, Gourbeyre Ophélie, Meynard Delphine, Martin Patricia, Oswald Eric, Coppin Hélène, Roth Marie-Paule

机构信息

IRSD (Institut de Recherche en Santé Digistive), Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France; and.

Laboratoire de Bactériologie-Hygiène, CHU Toulouse, Toulouse, France.

出版信息

Blood. 2017 Jan 26;129(4):533-536. doi: 10.1182/blood-2016-10-748541. Epub 2016 Nov 30.

DOI:10.1182/blood-2016-10-748541

PMID:27903526

Abstract

摘要

相似文献

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

Blood. 2017 Jan 26;129(4):533-536. doi: 10.1182/blood-2016-10-748541. Epub 2016 Nov 30.

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.

Blood. 2012 Jul 12;120(2):431-9. doi: 10.1182/blood-2012-02-411470. Epub 2012 May 18.

Regulation of hepcidin expression by inflammation-induced activin B.

Sci Rep. 2016 Dec 6;6:38702. doi: 10.1038/srep38702.

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.

Endocrinology. 2016 Mar;157(3):1146-62. doi: 10.1210/en.2015-1747. Epub 2016 Jan 6.

Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.

J Am Soc Nephrol. 2016 Mar;27(3):835-46. doi: 10.1681/ASN.2014101035. Epub 2015 Aug 20.

Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation.

Haematologica. 2015 Feb;100(2):e68-71. doi: 10.3324/haematol.2014.111484. Epub 2014 Oct 17.

Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling.

Blood. 2018 Oct 25;132(17):1829-1841. doi: 10.1182/blood-2018-03-841197. Epub 2018 Sep 13.

Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice.

Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G132-9. doi: 10.1152/ajpgi.00256.2013. Epub 2013 Nov 27.

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

Hepatology. 2009 Dec;50(6):1992-2000. doi: 10.1002/hep.23198.

Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice.

Am J Hematol. 2019 Feb;94(2):240-248. doi: 10.1002/ajh.25366. Epub 2018 Dec 10.

引用本文的文献

Luspatercept (RAP-536) modulates oxidative stress without affecting mutation burden in myelodysplastic syndromes.

Ann Hematol. 2022 Dec;101(12):2633-2643. doi: 10.1007/s00277-022-04993-7. Epub 2022 Oct 5.

Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study.

Antioxidants (Basel). 2022 Jul 14;11(7):1364. doi: 10.3390/antiox11071364.

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications.

Nanomaterials (Basel). 2021 Nov 4;11(11):2958. doi: 10.3390/nano11112958.

Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice.

Front Cell Infect Microbiol. 2021 Jul 23;11:705087. doi: 10.3389/fcimb.2021.705087. eCollection 2021.

Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders.

Br J Haematol. 2021 Jun;193(5):882-893. doi: 10.1111/bjh.17252. Epub 2020 Dec 14.

Bone morphogenic proteins in iron homeostasis.

Bone. 2020 Sep;138:115495. doi: 10.1016/j.bone.2020.115495. Epub 2020 Jun 23.

Extrahepatic hepcidin production: The intriguing outcomes of recent years.

World J Clin Cases. 2019 Aug 6;7(15):1926-1936. doi: 10.12998/wjcc.v7.i15.1926.

Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.

Hepatology. 2019 Dec;70(6):1986-2002. doi: 10.1002/hep.30780. Epub 2019 Aug 13.

The Importance of Iron Status for Young Children in Low- and Middle-Income Countries: A Narrative Review.

Pharmaceuticals (Basel). 2019 Apr 16;12(2):59. doi: 10.3390/ph12020059.

Hepcidin Therapeutics.

Pharmaceuticals (Basel). 2018 Nov 21;11(4):127. doi: 10.3390/ph11040127.

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

作者信息

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出版信息

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Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

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