[苯佐呋卡因、苯卡贝兰和邻苯酚的抗氧化性能]

[Antioxidant properties of benzofurocaine, phenycaberan and orthophen].

作者信息

Lebedev A V, Kuz'min A V, Levitskiĭ D O, Stepaniuk G I

出版信息

Farmakol Toksikol. 1989 May-Jun;52(3):59-62.

Abstract

The antioxidant properties of benzofurocaine, phenycaberan, crithophen, alpha-tocopherol and ionol were evaluated by inhibition of oxygen absorption by liposomes from egg phosphatidylcholine induced by the addition of an prooxidant. The activity of the tested agents at inhibition of Fe2+-ascorbater-initiated oxidation decreases in the order: ionol, benzofurocaine, phenycaberan, orthophen, alpha-tocopherol; emine-initiated (EDTA-independent) oxidation of phosphatidylcholine is inhibited only by ionol, orthophen and alpha-tocopherol. Phenycaberan exerts no effect on oxidation and benzofurocaine increases the rate of emine-initiated absorption of oxygen. Thus, benzofurocaine, phenycaberan and orthophen may be referred to as selective inhibitors of Fe2+-initiated peroxidation of phosphatidylcholine.

摘要

通过抑制由添加促氧化剂诱导的卵磷脂脂质体的氧吸收，评估了苯并呋喃卡因、苯卡贝兰、克里托芬、α-生育酚和紫罗兰酮的抗氧化性能。受试药剂对Fe2 + -抗坏血酸引发的氧化的抑制活性按以下顺序降低：紫罗兰酮、苯并呋喃卡因、苯卡贝兰、邻苯酚、α-生育酚；磷脂酰胆碱的乙二胺引发的（不依赖于乙二胺四乙酸）氧化仅被紫罗兰酮、邻苯酚和α-生育酚抑制。苯卡贝兰对氧化无影响，而苯并呋喃卡因增加了乙二胺引发的氧吸收速率。因此，苯并呋喃卡因、苯卡贝兰和邻苯酚可被称为磷脂酰胆碱Fe2 +引发的过氧化的选择性抑制剂。