Masaoka T, Amano K, Takedani H, Suzuki T, Otaki M, Seita I, Tateiwa T, Shishido T, Yamamoto K, Fukutake K
Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan.
Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.
Haemophilia. 2017 Mar;23(2):e116-e123. doi: 10.1111/hae.13135. Epub 2016 Dec 11.
Detecting signs of joint deterioration is important for early effective orthopaedic intervention in managing haemophilic arthropathy.
We developed a simple, patient self-administered sheet to evaluate the joint condition, and assessed the predictive ability of this assessment sheet for the need for an orthopaedic intervention.
This was a single-centre, cross-sectional study. The association between the score of each of the four items of the assessment sheet (bleeding, swelling, pain and physical impairment) and the results of radiological findings and physical examinations based on Haemophilia Joint Health Score 2.1 was assessed. An optimal scoring system was explored by the area under the curve (AUC). The cut-off value for the need for surgery or physiotherapy was determined using the receiver operating characteristic curve procedure.
Forty-two patients were included. The 'physical impairment' item showed the highest correlation coefficient with the results of radiographic and physical examinations (range: 0.57-0.76). The AUC of finally adjusted scoring indicates good ability to discriminate between patients with and without a need for orthopaedic intervention. The positive predictive value was the highest at a cut-off value of 4 points for knees (63.0%) and ankles (70.0%), at 5 points for elbows (66.7%) and the highest predictive accuracy at the cut-off value of 4 points for all the joints. The linear trend of the need for an orthopaedic intervention was observed with an increasing score.
The joint condition assessment sheet can help clinicians assess the need for orthopaedic intervention for haemophilic arthropathy in Japanese patients with haemophilia.
检测关节退变迹象对于血友病性关节病的早期有效骨科干预至关重要。
我们开发了一种简单的患者自我管理表格来评估关节状况,并评估该评估表对骨科干预需求的预测能力。
这是一项单中心横断面研究。评估了评估表四项内容(出血、肿胀、疼痛和身体功能障碍)各自的评分与基于血友病关节健康评分2.1的放射学检查结果和体格检查结果之间的关联。通过曲线下面积(AUC)探索最佳评分系统。使用受试者工作特征曲线程序确定手术或物理治疗需求的临界值。
纳入42例患者。“身体功能障碍”项目与放射学和体格检查结果的相关系数最高(范围:0.57 - 0.76)。最终调整评分的AUC表明其具有良好的区分有无骨科干预需求患者的能力。对于膝关节,临界值为4分时阳性预测值最高(63.0%);对于踝关节,临界值为4分时阳性预测值最高(70.0%);对于肘关节,临界值为5分时阳性预测值最高(66.7%);对于所有关节,临界值为4分时预测准确性最高。随着评分增加,观察到骨科干预需求的线性趋势。
关节状况评估表可帮助临床医生评估日本血友病患者血友病性关节病的骨科干预需求。