Association between status and metachronous gastric cancer after endoscopic resection.

AIM

To investigate the effect of () status test and eradication on the occurrence of metachronous gastric cancer (MGC) after endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) and risk factors of MGC.

METHODS

The authors retrospectively reviewed the medical records of 433 patients (441 lesions) who underwent ESD for EGC from January 2005 to January 2015 in Yeungnam University Hospital. Patients were categorized into two groups; the tested group ( = 257) and the non-tested group ( = 176) based on performance of status test after ESD of EGC. The tested group was further categorized into three subgroups based on status; the -eradicated subgroup ( = 120), the -persistent subgroup ( = 42), and the -negative subgroup ( = 95). Incidences of MGC and risk factors of MGC were identified.

RESULTS

Median follow-up duration after ESD was 30.00 mo (range, 6-107 mo). Total 15 patients developed MGC during follow-up. MGC developed in 11 patients of the tested group (7 in the -negative subgroup, 3 in the -eradicated subgroup, and 1 in the -persistent subgroup) and 4 patients of the non-tested group ( > 0.05). The risk factors of MGC were endoscopic mucosal atrophy in the tested group and intestinal metaplasia in all patients.

CONCLUSION

eradication and status test seems to have no preventive effect on the development of MGC after ESD for EGC. The risk factors of MGC development were endoscopic mucosal atrophy in the tested group alone and intestinal metaplasia in all patients.