Snail和NF-κB的高表达预示着中国肝细胞癌患者的预后不良。

Zhang Min, Dong Xin, Zhang Dengcai, Chen Xiaojie, Zhu Xinyu

Department of Pathology, Department of Scientific Research Gansu Provincial Hospital, Lanzhou 730000, P.R. China.

Department of Scientific Research, Gansu Provincial Hospital, Lanzhou 730000, P.R. China.

Oncotarget. 2017 Jan 17;8(3):4543-4548. doi: 10.18632/oncotarget.13891.

In this study, we explored the roles of Snail and NF-κB in hepatocellular carcinoma (HCC). Samples of HCC tumor tissue were collected from 83 Chinese HCC patients. Snail and NF-κB expression was then examined based on immunohistochemical staining, and the relations between Snail and NF-κB expression and the clinical characteristics of the patients were assessed using Cox model analysis. Snail and NF-κB were both expressed in HCC tissue, and their levels were strongly correlated. In addition, levels of both Snail and NF-κB expression were negatively related to tumor differentiation, which was an independent factor predictive of survival in HCC patients. Snail and NF-κB may thus be useful markers of tumor differentiation and survival in HCC, and may also be useful for guiding treatment and exploring molecular mechanisms.

在本研究中，我们探讨了Snail和核因子κB（NF-κB）在肝细胞癌（HCC）中的作用。从83例中国HCC患者中收集HCC肿瘤组织样本。然后基于免疫组织化学染色检测Snail和NF-κB的表达，并使用Cox模型分析评估Snail和NF-κB表达与患者临床特征之间的关系。Snail和NF-κB均在HCC组织中表达，且它们的水平呈强相关。此外，Snail和NF-κB的表达水平均与肿瘤分化呈负相关，肿瘤分化是HCC患者生存的独立预测因素。因此，Snail和NF-κB可能是HCC中肿瘤分化和生存的有用标志物，也可能有助于指导治疗和探索分子机制。