[Changes of macrophage function after graded physical loading].

Intensive physical loading (swimming for 3.5 hours with a load amounting to 4% of body weight for rats and for 1 hour without a load for mice) reduced 5-6-fold the clearing function of the mononuclear phagocyte system of untrained animals. The absorption function of Kupffer's cells diminished 2-fold, whereas clearance through macrophages of the lung interstitium was activated. Kupffer's cells of trained animals (daily swimming for 1 hour for 10 days) acquired tolerance to loading. Preliminary administration of zymosan (3-14 days before intensive physical loading) increased the animals' resistance to stress 2-3-fold.