State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China.
Trends Microbiol. 2017 Apr;25(4):293-303. doi: 10.1016/j.tim.2016.11.013. Epub 2016 Dec 13.
The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell-cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substantial progress has been made on the characterization of new members of this family of signals. There have also been new developments in the understanding of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the use of various substrates have been described. The recent discovery of a naturally occurring DSF turnover mechanism and its regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modulate virulence gene expression in response to changes in the surrounding environment.
基于可扩散信号因子（DSF）的群体感应（QS）系统已成为革兰氏阴性细菌中广泛保守的细胞间通讯机制。通常，DSF 家族的信号是顺式-2-不饱和脂肪酸，它们调节多种生物学功能。最近，在该信号家族新成员的特征描述方面取得了重大进展。在这些分子的生物合成方面也有了新的认识，描述了 DSF 合酶的双重酶活性和各种底物的使用。最近发现了一种自然存在的 DSF 周转机制及其调控，为我们理解 DSF 依赖性微生物如何根据周围环境的变化调节毒力基因表达提供了一个新的维度。
