García-Villarreal Ovidio A, Heredia-Delgado José A
Departamento de Cirugía Cardiaca, Hospital de Cardiología UMAE 34, Instituto Mexicano del Seguro Social, , Monterrey, Nuevo León, México.
Departamento de Cirugía Cardiaca, Hospital de Cardiología UMAE 34, Instituto Mexicano del Seguro Social, , Monterrey, Nuevo León, México.
Arch Cardiol Mex. 2017 Oct-Dec;87(4):286-291. doi: 10.1016/j.acmx.2016.11.007. Epub 2016 Dec 13.
To demonstrate that surgical removal of the left atrial appendage in patients with rheumatic mitral valve disease and long standing persistent atrial fibrillation decreases the possibility of stroke. This also removes the need for long-term oral anticoagulation after surgery.
A descriptive, prospective, observational study was conducted on 27 adult patients with rheumatic mitral valve disease and long standing persistent atrial fibrillation, who had undergone mitral valve surgery and surgical removal of the left atrial appendage. Oral anticoagulation was stopped in the third month after surgery. The end-point was the absence of embolic stroke. An assessment was also made of postoperative embolism formation in the left atrium using transthoracic echocardiography.
None of the patients showed embolic stroke after the third post-operative month. Only one patient exhibited transient ischaemic attack on warfarin therapy within the three postoperative months. Left atrial thrombi were also found in 11 (40.7%) cases during surgery. Of these, 6 (54.5%) had had embolic stroke, with no statistical significance (P=.703).
This study suggests there might be signs that the left atrial appendage may be the main source of emboli in rheumatic mitral valve disease, and its resection could eliminate the risk of stroke in patients with rheumatic mitral valve disease and long-standing persistent atrial fibrillation.
证明对风湿性二尖瓣疾病合并长期持续性房颤患者进行左心耳手术切除可降低中风风险。这也消除了术后长期口服抗凝治疗的必要性。
对27例患有风湿性二尖瓣疾病并长期持续性房颤的成年患者进行了一项描述性、前瞻性观察性研究,这些患者接受了二尖瓣手术及左心耳手术切除。术后第三个月停止口服抗凝治疗。终点指标为无栓塞性中风。还使用经胸超声心动图对术后左心房内的栓塞形成情况进行了评估。
术后第三个月后,所有患者均未出现栓塞性中风。仅1例患者在术后三个月内接受华法林治疗时出现短暂性脑缺血发作。手术期间还发现11例(40.7%)患者存在左心房血栓。其中6例(54.5%)曾发生栓塞性中风,无统计学意义(P = 0.703)。
本研究表明,可能有迹象显示左心耳可能是风湿性二尖瓣疾病中栓子的主要来源,切除左心耳可消除风湿性二尖瓣疾病合并长期持续性房颤患者的中风风险。