Facchetti Luca, Schwaiger Benedikt J, Gersing Alexandra S, Guimaraes Julio Brandao, Nardo Lorenzo, Majumdar Sharmila, Ma Benjamin C, Link Thomas M, Li Xiaojuan
Department of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Department of Radiology, University of Brescia, Brescia, Italy.
Eur Radiol. 2017 Aug;27(8):3499-3508. doi: 10.1007/s00330-016-4661-3. Epub 2016 Dec 16.
To assess the impact of cyclops lesions with MRI in patients treated for anterior cruciate ligament (ACL) tears on clinical outcome.
In 113 patients (age 29.8 ± 10.5y; 55 females; BMI 24.8 ± 3.7 kg/m) with complete ACL tear, 3 T-MRI scans were obtained before, 6-months, 1-year (n = 75) and 2-years (n = 33) after ACL reconstruction. Presence and volume of cyclops lesions were assessed. Clinical outcomes were measured using the Knee injury and Osteoarthritis Outcome Score (KOOS) and differences between time points (∆KOOS) were calculated. Changes of KOOS subscales were compared between patients with and without cyclops lesion. KOOS was also correlated with lesion volume.
Cyclops lesions were found in 25% (28/113), 27% (20/75) and 33% (11/33) of patients after 6-months, 1- and 2-years, respectively. The lesion volume did not change significantly (P > 0.05) between time points, measuring 0.65 ± 0.59, 0.81 ± 0.70 and 0.72.9 ± 0.96 cm, respectively. Clinical outcomes based on KOOS subscales were not significantly different in patients with cyclops lesions compared to those without cyclops lesions (each comparison P > 0.05), and no significant associations of clinical outcomes with lesion volume were found (P > 0.05).
Neither presence nor size of cyclops lesions within the first 2-years after ACL surgery were associated with inferior clinical outcome.
• Cyclops lesions had a prevalence of 25% in patients after ACL reconstruction. • Subjects with cyclops lesions did not have an inferior clinical outcome. • Cyclops lesions developed within the first 6 months after surgery. • The size of cyclops lesions did not significantly change over a period of 2 years.
评估前交叉韧带（ACL）撕裂患者接受治疗后，磁共振成像（MRI）显示的独眼巨人病变对临床疗效的影响。
对113例完全性ACL撕裂患者（年龄29.8±10.5岁；55例女性；体重指数24.8±3.7kg/m²）在ACL重建术前、术后6个月、1年（n = 75）和2年（n = 33）进行3T-MRI扫描。评估独眼巨人病变的存在情况和体积。使用膝关节损伤和骨关节炎疗效评分（KOOS）测量临床疗效，并计算各时间点之间的差异（∆KOOS）。比较有和没有独眼巨人病变的患者KOOS子量表的变化。KOOS还与病变体积相关。
分别在术后6个月、1年和2年的患者中发现独眼巨人病变的比例为25%（28/）、27%（20/75）和33%（11/33）。各时间点之间病变体积无显著变化（P>0.05），分别为0.65±0.59、0.81±0.70和0.729±0.96cm³。与没有独眼巨人病变的患者相比，有独眼巨人病变的患者基于KOOS子量表的临床疗效无显著差异（每次比较P>0.05），且未发现临床疗效与病变体积有显著关联（P>0.05）。
ACL手术后2年内，独眼巨人病变的存在与否及大小均与较差的临床疗效无关。
• ACL重建术后患者中独眼巨人病变的发生率为25%。• 有独眼巨人病变的受试者临床疗效并不差。• 独眼巨人病变在术后最初6个月内形成。• 独眼巨人病变的大小在2年内无显著变化。
