胎儿肺T2信号增加并非由于表面活性剂浓度升高：一项体外T2成像分析。
Increased fetal lung T2 signal is not due to increasing surfactant concentration: an in vitro T2 mapping analysis.
作者信息
Dubinsky Theodore J, Moshiri Mariam, Adams Waldorf Kristina, Wilson Greg, Maki Jeffrey H, Hippe Daniel S
机构信息
Department of Radiology, University of Washington, Seattle, WA, USA.
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
出版信息
Prenat Diagn. 2017 Mar;37(3):211-214. doi: 10.1002/pd.4987. Epub 2017 Jan 25.
OBJECT
The aim of this study was to perform in vitro T2 mapping of serial dilutions of pharmaceutical surfactant.
MATERIALS AND METHODS
Magnetic resonance imaging. Magnetic resonance scanning was performed on serial dilutions of surfactant on large bore clinical magnets at a field strength of 1.5 T Philips and 3.0 T (Achieva TX, Philips Healthcare, the Netherlands).
RESULTS
The curves demonstrate a small increasing trend between surfactant concentration and R2 (shortened T2's), with a 7.3% increase in R2 for each doubling of surfactant concentration (95% confidence interval: 6.1-8.6%, p < 0.001).
CONCLUSIONS
The increasing lung/liver T2 signal ratio seen in fetal lungs with increasing gestational age is not due to increasing surfactant concentration. © 2016 John Wiley & Sons, Ltd.
目的
本研究旨在对药用表面活性剂的系列稀释液进行体外T2映射。
材料与方法
磁共振成像。在1.5 T飞利浦大孔径临床磁体以及3.0 T（Achieva TX，飞利浦医疗保健公司，荷兰）上对表面活性剂的系列稀释液进行磁共振扫描。
结果
曲线显示表面活性剂浓度与R2（T2缩短）之间呈小幅上升趋势，表面活性剂浓度每增加一倍，R2增加7.3%（95%置信区间：6.1 - 8.6%，p < 0.001）。
结论
随着胎龄增加，胎儿肺中肺/肝T2信号比增加并非由于表面活性剂浓度增加。© 2016约翰威立父子有限公司
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