氨氯地平降低了近足月大鼠胎盘对钠的母胎清除率。

Amiloride reduces maternofetal clearance of sodium across the near-term rat placenta.

作者信息

Atkinson D E, Sibley C P, Robinson N R

机构信息

Department of Child Health, St Mary's Hospital, University of Manchester.

出版信息

Q J Exp Physiol. 1989 Jul;74(4):557-60. doi: 10.1113/expphysiol.1989.sp003305.

DOI:10.1113/expphysiol.1989.sp003305

PMID:2798765

Abstract

The effect of amiloride on unidirectional maternofetal clearance across the perfused placenta has been studied in rats at 21 days gestation. A bolus dose of 1 mg kg-1 followed by an infusion of 0.6 mg h-1 into the maternal circulation caused a significant (P less than 0.02) decrease in 22Na clearance by 8%, whilst having no effect on the clearance of 51Cr-EDTA; a ten times higher dose of amiloride (10 mg kg-1, 6 mg h-1) did not reduce 22Na clearance further. Similar administration of an equivalent volume of saline to control animals showed no effect on either Na+ or Cr-EDTA clearances.

摘要

在妊娠21天的大鼠中，研究了氨氯地平对经灌注胎盘的单向母胎清除率的影响。在母体循环中静脉注射1 mg/kg的大剂量氨氯地平，随后以0.6 mg/h的速度输注，导致22Na清除率显著降低（P<0.02），降低了8%，而对51Cr-EDTA的清除率没有影响；剂量为氨氯地平10倍（10 mg/kg，6 mg/h）时，22Na清除率没有进一步降低。向对照动物注射等体积的生理盐水，对Na+或Cr-EDTA的清除率均无影响。