直接测定人唾液中的3-甲氧基-4-羟基苯乙二醇（MHPG）；评估去甲肾上腺素能功能的新方法。
Direct assay of 3-methoxy-4-hydroxy-phenylglycol (MHPG) in human saliva; a new approach in the assessment of noradrenergic function.
作者信息
Stefănescu A M, Popa M, Dumitriu L
机构信息
C.I. Parhon Institute of Endocrinology, Bucharest, Romania.
出版信息
Endocrinologie. 1989 Apr-Jun;27(2):93-6.
The present paper offers a simple, reliable and specific method for the evaluation of salivary level of conjugated MHPG in 16 children (5-16 years) selected as control group. In the chosen group, we established the urinary level of NA: 17.64 +/- 1.38 micrograms/24 h, of A: 5.87 +/- 0.44 micrograms/24 h, of MHPG: 1.62 +/- 0.14 mg/24 h, of VMA: 1.54 +/- 10.10 mg/24 h. In all patients we assayed salivary MHPG: 57 +/- 5.25 mg/ml; in only 6 patients we also determined salivary NA: 2.21 +/- 0.11 micrograms/l and A: 0.25 +/- 0.03 micrograms/l. The MHPG in saliva correlates with urinary MHPG but doesn't correlate with NA in saliva or in urine. The assay of salivary MHPG may represent a non-invasive procedure of evaluation of noradrenergic tonus in children.
本文提供了一种简单、可靠且特异的方法，用于评估选定为对照组的16名儿童（5至16岁）唾液中结合型3-甲氧基-4-羟基苯乙二醇（MHPG）的水平。在选定的组中，我们测定了尿中去甲肾上腺素（NA）的水平为17.64±1.38微克/24小时，肾上腺素（A）为5.87±0.44微克/24小时，MHPG为1.62±0.14毫克/24小时，香草扁桃酸（VMA）为1.54±10.10毫克/24小时。在所有患者中，我们测定了唾液中MHPG的水平为57±5.25毫克/毫升；仅在6名患者中还测定了唾液中NA的水平为2.21±0.11微克/升和A的水平为0.25±0.03微克/升。唾液中的MHPG与尿中的MHPG相关，但与唾液或尿中的NA不相关。唾液中MHPG的测定可能代表一种评估儿童去甲肾上腺素能张力的非侵入性方法。
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