Long Whitney M, Sinnott Virginia B, Bracker Kiko, Thomas Danielle
Angell Animal Medical Center, 350 South Huntington Avenue, Boston, MA, 02130.
J Vet Emerg Crit Care (San Antonio). 2017 May;27(3):357-361. doi: 10.1111/vec.12562. Epub 2016 Dec 19.
To describe the successful treatment of loperamide toxicosis in a dog using intravenous lipid emulsion (ILE).
An 8-month-old male neutered Rough Collie weighing 20.0 kg was given a total dose of 0.75 mg/kg loperamide over 3 days as treatment for diarrhea. The dog was subsequently evaluated for signs of dull mentation, anxiety, ptyalism and ataxia, thought to be a result of loperamide intoxication. The dog was treated with a 1.5 mL/kg IV bolus of 20% ILE solution followed by 0.25 mL/kg/min of the same solution for 2 hours. The dog's mentation improved rapidly following ILE infusion, and he was neurologically normal 3 hours after initiation of ILE treatment. The dog was subsequently found to be homozygous for the ATP-binding cassette (ABC) transporter gene (ABCB1-1∆) mutation. There were no adverse effects noted during or following ILE infusion.
ILE was successful in the treatment of loperamide toxicosis in a Collie with the ABCB1-1∆ mutation. ILE may be of benefit for treatment of other intoxications in dogs with ABCB1-1Δ mutations.
描述使用静脉注射脂质乳剂（ILE）成功治疗犬洛哌丁胺中毒的情况。
一只8个月大、体重20.0千克的去势雄性粗毛柯利牧羊犬，在3天内共接受了0.75毫克/千克的洛哌丁胺治疗腹泻。随后该犬因精神沉郁、焦虑、流涎和共济失调等症状接受评估，这些症状被认为是洛哌丁胺中毒所致。给该犬静脉推注1.5毫升/千克的20% ILE溶液，随后以0.25毫升/千克/分钟的相同溶液持续输注2小时。ILE输注后该犬的精神状态迅速改善，在开始ILE治疗3小时后其神经系统恢复正常。随后发现该犬的ATP结合盒（ABC）转运蛋白基因（ABCB1-1∆）突变呈纯合子状态。在ILE输注期间及之后未观察到不良反应。
ILE成功治疗了一只患有ABCB1-1∆突变的柯利牧羊犬的洛哌丁胺中毒。ILE可能对治疗患有ABCB1-1Δ突变的犬的其他中毒情况有益。
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