Department of Urology, Boston Children's Hospital, Boston, Massachusetts.
Division of Urology, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
J Urol. 2017 Mar;197(3 Pt 2):906-910. doi: 10.1016/j.juro.2016.07.085. Epub 2016 Dec 16.
There are sparse data directly comparing the probability of renal injury in children and adults. The kidney of the child is believed to be more susceptible to blunt injury for a variety of anatomical reasons. In a large cohort we tested the hypothesis that the pediatric kidney is more susceptible to any renal injury and to higher grade injury.
We queried the NTDB® (National Trauma Data Bank®) on all hospital admissions following motor vehicle collisions in a pediatric population (age less than 21 years) and a referent adult population (age 30 to 50 years). Of 111,172 children who were admitted after motor vehicle collisions 1,093 had renal injury.
Of the 111,172 children admitted to the hospital following motor vehicle collisions 59,385 had abdominal trauma and 1,093 had renal injury. In a multivariate logistic model adjusting for overall ISS (Injury Severity Score), region, year, driver/passenger status, presence of restraint or an airbag, we found that children had 48% higher odds of renal injury compared to adults ages 30 to 50 years (OR 1.48, 95% CI 1.32-1.66, p <0.001). Furthermore, children were at 33% higher risk for high grade renal injury (OR 1.33, 95% CI 1.05-1.69, p = 0.919). The effect remained when restricting analysis to patients with concomitant liver and spleen injuries (p <0.001).
In a large national cohort of children, blunt renal injury following motor vehicle collisions is rare but substantially more common than in adults. The odds of high grade renal injury are approximately 50% higher in children. A greater index of suspicion and a lower threshold for renal imaging is prudent for children with blunt abdominal trauma from motor vehicle collisions.
直接比较儿童和成人肾损伤概率的相关数据较为匮乏。由于多种解剖学原因,儿童的肾脏被认为更容易受到钝性损伤。在一项大型队列研究中,我们检验了以下假说,即儿童的肾脏更容易发生任何程度的肾损伤和更严重的肾损伤。
我们在国家创伤数据库(National Trauma Data Bank®)中查询了儿童(年龄小于 21 岁)和成人(30 至 50 岁)人群因机动车碰撞导致的所有住院病例。在 111172 例因机动车碰撞而住院的儿童中,有 1093 例发生了肾损伤。
在因机动车碰撞而住院的 111172 例儿童中,59385 例有腹部外伤,1093 例有肾损伤。在调整总体 ISS(损伤严重度评分)、区域、年份、驾驶员/乘客状态、约束或安全气囊的存在等因素的多变量逻辑回归模型中,我们发现儿童发生肾损伤的可能性比 30 至 50 岁的成人高 48%(比值比 1.48,95%置信区间 1.32-1.66,p<0.001)。此外,儿童发生重度肾损伤的风险增加了 33%(比值比 1.33,95%置信区间 1.05-1.69,p=0.019)。当将分析限制在伴有肝脾损伤的患者时,这种效应仍然存在(p<0.001)。
在一项大型全国儿童队列研究中,机动车碰撞后钝性肾损伤较为罕见,但明显比成人更常见。儿童发生重度肾损伤的几率大约高 50%。对于因机动车碰撞导致的钝性腹部外伤的儿童,应保持更高的警惕性,且对肾脏影像学检查的门槛应更低。