用于动脉粥样硬化成像的PET/SPECT探针开发的最新进展
Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging.
作者信息
Shimizu Yoichi, Kuge Yuji
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Central Institute of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-0815 Japan ; Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
Nucl Med Mol Imaging. 2016 Dec;50(4):284-291. doi: 10.1007/s13139-016-0418-9. Epub 2016 Apr 26.
The rupture of vulnerable atherosclerotic plaques and subsequent thrombus formation are the major causes of myocardial and cerebral infarction. Accordingly, the detection of vulnerable plaques is important for risk stratification and to provide appropriate treatment. Inflammation imaging using 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) has been most extensively studied for detecting vulnerable atherosclerotic plaques. It is of great importance to develop PET/SPECT probes capable of specifically visualizing the biological molecules involved in atherosclerotic plaque formation and/or progression. In this article, we review recent advances in the development of PET/SPECT probes for visualizing atherosclerotic plaques and their application to therapy monitoring, mainly focusing on experimental studies.
易损动脉粥样硬化斑块的破裂及随后的血栓形成是心肌梗死和脑梗死的主要原因。因此，检测易损斑块对于风险分层和提供适当治疗很重要。使用2-脱氧-2-[F]氟-D-葡萄糖（F-FDG）的炎症成像在检测易损动脉粥样硬化斑块方面得到了最广泛的研究。开发能够特异性可视化参与动脉粥样硬化斑块形成和/或进展的生物分子的PET/SPECT探针非常重要。在本文中，我们综述了用于可视化动脉粥样硬化斑块的PET/SPECT探针开发的最新进展及其在治疗监测中的应用，主要侧重于实验研究。
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