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一名未接受腹膜透析的糖尿病控制不佳女性出现罕见的肝包膜下脂肪变性:病例报告

Rare presentation of subcapsular hepatic steatosis in a woman with uncontrolled diabetes without peritoneal dialysis: a case report.

作者信息

Chowdhary Varun, Pernicka Jennifer S Golia, Sharma Richa

机构信息

Department of Radiology, Staten Island University Hospital, Northwell Health, 475 Seaview Ave, New York City, NY, 10305, USA.

出版信息

J Med Case Rep. 2016 Dec 20;10(1):370. doi: 10.1186/s13256-016-1152-8.

Abstract

BACKGROUND

Subcapsular hepatic steatosis is a rare atypical pattern of fatty deposition of the liver reported in patients with diabetic nephropathy receiving peritoneal dialysis with intraperitoneal insulin. To date, there has been only one pediatric and zero adult cases of subcapsular hepatic steatosis with no history of continuous ambulatory peritoneal dialysis. We report the first published case of subcapsular hepatic steatosis in an adult diabetic patient without any history of peritoneal dialysis or evidence of chronic renal disease.

CASE PRESENTATION

A 46-year-old Caucasian woman with type 2 diabetes mellitus without renal disease presented to our emergency department with vague abdominal symptoms and vomiting. Her blood glucose levels were poorly controlled with a range of 400 to 500 mg/dL. She was diagnosed as having subcapsular hepatic steatosis based on magnetic resonance imaging. Of note, after improved glucose control her subcapsular hepatic steatosis had nearly resolved.

CONCLUSIONS

Subcapsular hepatic steatosis has been exclusively described in patients with continuous ambulatory peritoneal dialysis and those on intraperitoneal insulin, except for one pediatric case, which was probably due to incorrect insulin administration. Our case demonstrates that a diagnosis of subcapsular hepatic diagnosis should not be restricted to those getting continuous ambulatory peritoneal dialysis, but rather expanded to all patients with uncontrolled blood glucose levels.

摘要

背景

肝包膜下脂肪变性是一种罕见的非典型肝脏脂肪沉积模式,见于接受腹膜内胰岛素治疗的糖尿病肾病患者。迄今为止,仅有1例小儿肝包膜下脂肪变性病例,尚无无持续非卧床腹膜透析史的成人病例报道。我们报告首例无腹膜透析史或慢性肾病证据的成年糖尿病患者肝包膜下脂肪变性病例。

病例介绍

一名46岁无肾病的2型糖尿病白人女性因腹部症状模糊和呕吐就诊于我院急诊科。她的血糖水平控制不佳,范围在400至500mg/dL之间。基于磁共振成像,她被诊断为肝包膜下脂肪变性。值得注意的是,血糖控制改善后,她的肝包膜下脂肪变性几乎消退。

结论

除1例可能因胰岛素给药不当的小儿病例外,肝包膜下脂肪变性仅在持续非卧床腹膜透析患者和接受腹膜内胰岛素治疗的患者中被描述。我们的病例表明,肝包膜下脂肪变性的诊断不应局限于接受持续非卧床腹膜透析的患者,而应扩大到所有血糖控制不佳的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5897/5175298/50231e61aedb/13256_2016_1152_Fig1_HTML.jpg

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本文引用的文献

1
Hepatic subcapsular steatosis: a rare complication of high dose insulin therapy.
J Pediatr Endocrinol Metab. 2012;25(11-12):1201-4. doi: 10.1515/jpem-2012-0179.
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Imaging appearance of severe subcapsular hepatic steatosis: mimicking hepatic embolic infarcts.
Br J Radiol. 2010 May;83(989):e98-100. doi: 10.1259/bjr/62944791.
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Hepatic subcapsular steatosis in response to intraperitoneal insulin delivery: CT findings and prevalence.
AJR Am J Roentgenol. 2003 Jun;180(6):1601-4. doi: 10.2214/ajr.180.6.1801601.

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