早期临床应答可预测急性细菌性皮肤和皮肤结构感染患者的晚期治疗成功：两项随机对照试验的回顾性分析。
Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials.
机构信息
Ninewells Hospital and Medical School, Dundee, United Kingdom.
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina.
出版信息
Clin Infect Dis. 2017 Jan 15;64(2):214-217. doi: 10.1093/cid/ciw750. Epub 2016 Dec 21.
UNLABELLED
In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation.
CLINICAL TRIALS REGISTRATION
NCT01170221; NCT01421511.
未加说明
在治疗急性细菌性皮肤和皮肤结构感染方面，来自 2 项临床试验（N=1333 例患者）的汇总数据表明，程序评估和研究者评估的早期治疗成功对于晚期临床治愈（包括住院患者）均具有很高的阳性预测值（94.3%-100.0%）。程序早期成功的阴性预测值<20%。这些探索性发现需要前瞻性的真实世界评估。
临床试验注册
NCT01170221；NCT01421511。
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