17q21位点rs7216389多态性与儿童哮喘风险：一项荟萃分析。
17q21 locus rs7216389 polymorphism and childhood asthma risk: a meta-analysis.
作者信息
Qu Yan-Liang, Ji You-Ran, Zhang Li-Xin, Wu Chun-Min, Wen Bao-Lei, Zhang Xin, Ma Chao, Wang De-Ming, Zhang Yuan-Xin, Zhou Xiang
机构信息
Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
Department of Anesthesiology, Wuhan General Hospital of People's Liberation Army of China, Wuhan, Hubei, China -
出版信息
Minerva Pediatr. 2018 Feb;70(1):98-102. doi: 10.23736/S0026-4946.16.04697-1. Epub 2016 Dec 22.
INTRODUCTION
Recently, a genome-wide association study (GWAS) indicated that rs7216389 polymorphism on chromosome 17q21 was associated with paediatric asthma risk. However, the results remained controversial. Therefore, a meta-analysis was performed.
EVIDENCE ACQUISITION
A comprehensive literature retrieve was performed on PubMed, Embase and Science Direct databases up to Feb 20, 2016. The strength of association between 17q21 locus rs7216389 polymorphism and pediatric asthma risk was assessed by computing odds ratio (OR) with its corresponding 95% confidence interval (CI).
EVIDENCE SYNTHESIS
A total of 10 studies with 7797 cases and 38757 controls were included. A statistically significant association of rs7216389 polymorphism and pediatric asthma risk was found (OR=1.41, 95%CI=1.34-1.49, P<0.00001). Furthermore, both Caucasians (OR=1.41, 95%CI=1.33-1.49, P<0.00001) and Asians (OR=1.43, 95%CI=1.25-1.63, P<0.00001) with rs7216389 polymorphism showed significant association, respectively. A significantly increased susceptibility was identified in atopic asthma (OR=1.45, 95%CI=1.22-1.72, P<0.00001). In the stratification analysis by study design, both case-control studies (OR=1.40, 95%CI=1.33-1.48, P<0.00001) and cohort studies (OR=2.05, 95%CI=1.32-3.17, P=0.001) showed significant association, respectively.
CONCLUSIONS
In conclusion, this meta-analysis suggests that 17q21 locus rs7216389 polymorphism was significantly associated with paediatric asthma risk.
引言
最近，一项全基因组关联研究（GWAS）表明，17号染色体q21区域的rs7216389多态性与儿童哮喘风险相关。然而，结果仍存在争议。因此，进行了一项荟萃分析。
证据获取
截至2016年2月20日，在PubMed、Embase和Science Direct数据库上进行了全面的文献检索。通过计算比值比（OR）及其相应的95%置信区间（CI），评估17q21位点rs7216389多态性与儿童哮喘风险之间的关联强度。
证据综合
共纳入10项研究，包括7797例病例和38757例对照。发现rs7216389多态性与儿童哮喘风险存在统计学显著关联（OR=1.41，95%CI=1.34-1.49，P<0.00001）。此外，携带rs7216389多态性的白种人（OR=1.41，95%CI=1.33-1.49，P<0.00001）和亚洲人（OR=1.43，95%CI=1.25-1.63，P<0.00001）分别显示出显著关联。在特应性哮喘中发现易感性显著增加（OR=1.45，95%CI=1.22-1.72，P<0.00001）。在按研究设计进行的分层分析中，病例对照研究（OR=1.40，95%CI=1.33-1.48，P<0.00001）和队列研究（OR=2.05，95%CI=1.32-3.17，P=0.001）均分别显示出显著关联。
结论
总之这项荟萃分析表明，17q21位点rs7216389多态性与儿童哮喘风险显著相关。
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