钛种植体表面分级微纳形貌结构对Beagle 犬即刻拔牙后骨整合的影响
The Effect of Hierarchical Micro/Nanotextured Titanium Implants on Osseointegration Immediately After Tooth Extraction in Beagle Dogs.
机构信息
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, P.R. China.
Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USA.
出版信息
Clin Implant Dent Relat Res. 2017 Jun;19(3):486-495. doi: 10.1111/cid.12464. Epub 2016 Dec 22.
BACKGROUND
Owing to simplify the operation and shorten the overall duration of treatment, immediate implantation earned much satisfactory from patients and dentists. The results of immediate implantation determined by osseointegration, we fabricated a micro/nanotextured titanium implants to improve osseointegration immediately after tooth extraction.
PURPOSE
The aim of this study was to investigate the effect of hierarchical micro/nanotextured titanium implant on osseointegration immediately after tooth extraction.
MATERIAL AND METHODS
The micro/nanotextured titanium implants were fabricated by etching with 0.5 wt% hydrofluoric (HF) acid followed by anodization in HF electrolytes. Implants with a machined surface as well as implants a microtextured surface prepared by 0.5 wt% HF etching served as control groups. The machined, microtextured, and micro/nanotextured implants were inserted into fresh sockets immediately after tooth extraction in beagle dogs. Twelve weeks after implantation, the animals were sacrificed for micro-CT scanning, histological analysis and biomechanical test.
RESULTS
The micro-CT imaging revealed that the bone volume/total volume (BV/TV) and trabecular thickness (Tb.Th) in the micro/nanotextured group was significantly higher than that in the machined group and microtextured group, and the trabecular separation (Tb.Sp) in the micro/nanotextured group was significantly lower than that in the other groups. For the histological analysis, the bone-to-implant contact in the machined, micro and micro/nanotextured groups were 47.13 ± 6.2%, 54.29 ± 4.18%, and 63.38 ± 7.63%, respectively, and the differences significant. The maximum pull-out force in the machined, micro, and micro/nanotextured groups were 216.58 ± 38.71 N, 259.42 ± 28.93 N, and 284.73 ± 47.09 N, respectively.
CONCLUSIONS
The results indicated that implants with a hierarchical micro/nanotextured can promote osseointegration immediately after tooth extraction.
背景
为了简化操作并缩短整体治疗时间，即刻种植术受到了患者和牙医的广泛认可。即刻种植术的效果取决于骨整合，我们制造了一种具有微纳结构的钛种植体，以在拔牙后立即改善骨整合。
目的
本研究旨在探讨即刻拔牙后具有分级微纳结构的钛种植体对骨整合的影响。
材料和方法
使用 0.5wt%氢氟酸（HF）蚀刻和在 HF 电解液中阳极氧化制造微纳结构钛种植体。具有机械加工表面的种植体和经过 0.5wt%HF 蚀刻制成微结构表面的种植体作为对照组。在比格犬拔牙后立即将机械加工、微结构和微纳结构的种植体插入新鲜牙槽窝中。植入 12 周后，处死动物进行 micro-CT 扫描、组织学分析和生物力学测试。
结果
micro-CT 成像显示，微纳结构组的骨体积/总体积（BV/TV）和骨小梁厚度（Tb.Th）明显高于机械加工组和微结构组，而微纳结构组的骨小梁分离度（Tb.Sp）明显低于其他组。组织学分析显示，机械加工组、微结构组和微纳结构组的骨-种植体接触率分别为 47.13±6.2%、54.29±4.18%和 63.38±7.63%，差异具有统计学意义。机械加工组、微结构组和微纳结构组的最大拔出力分别为 216.58±38.71N、259.42±28.93N 和 284.73±47.09N。
结论
结果表明，具有分级微纳结构的种植体可促进拔牙后即刻的骨整合。
Zotero 插件