Alchin David R, Murphy Declan, Lawrentschuk Nathan
University of Melbourne, Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia -
University of Melbourne, Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Minerva Urol Nefrol. 2017 Feb;69(1):56-62. doi: 10.23736/S0393-2249.16.02681-3. Epub 2016 Sep 28.
The number of men receiving radical prostatectomy (RP) in Victoria, Australia, increased seven-fold in the period 1993-2010, and increasingly robotic-assisted radical prostatectomy (RARP) is being utilized over the open and laparoscopic approaches. The longer-term oncological outcomes of RARP are beginning to be reported in the literature. The objective of this review was to determine whether any preoperative variables may be associated with the occurrence of positive surgical margins (PSMs) following RARP and how these may translate into subsequent risk of biochemical recurrence (BCR).
A systematic review of English articles from 2005 to present was performed through a MEDLINE search. Search terms included "positive surgical margins", "biochemical recurrence", "radical prostatectomy" and "prostate cancer".
All studies included for review were retrospective analyses of series that reported on rates of PSM and BCR achieved with RARP, and considered potential factors that may influence the rates observed.
RARP appears to confer lower rates of PSM when compared to the established approaches. Recent reports included in this review indicate that RARP should be able to provide excellent oncological outcomes as a result.
在1993年至2010年期间，澳大利亚维多利亚州接受根治性前列腺切除术（RP）的男性人数增加了七倍，与开放式和腹腔镜手术方法相比，机器人辅助根治性前列腺切除术（RARP）的使用越来越多。RARP的长期肿瘤学结果开始在文献中有所报道。本综述的目的是确定术前的任何变量是否可能与RARP术后手术切缘阳性（PSM）的发生相关，以及这些变量如何转化为随后的生化复发（BCR）风险。
通过MEDLINE搜索对2005年至今的英文文章进行了系统综述。搜索词包括“手术切缘阳性”、“生化复发”、“根治性前列腺切除术”和“前列腺癌”。
纳入综述的所有研究均为系列回顾性分析，报告了RARP实现的PSM和BCR发生率，并考虑了可能影响观察到的发生率的潜在因素。
与既定方法相比，RARP似乎能降低PSM的发生率。本综述中纳入的近期报告表明，RARP因此应该能够提供出色的肿瘤学结果。
