Yang Ya, Zhang Jia, Yan Yan, Cai Hui, Li Min, Sun Kai, Wang Jizhao, Liu Xu, Wang Jiansheng, Duan Xiaoyi
The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Department III of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Oncotarget. 2017 Jan 31;8(5):8057-8068. doi: 10.18632/oncotarget.14074.
Rap1GAP is a crucial tumor suppressor, but its role in gastric cancer (GC) is little investigated. In this study, we found that the expression of Rap1GAP was decreased in GC. Low expression of Rap1GAP was positively correlated with advanced pTNM stage, Borrmann types, tumor diameter and poor prognosis in patients with GC. Low expression of Rap1GAP correlated with loss of E-cadherin expression, and anomalous positivity of MMP2 expression. Multivariate analysis showed that low expression of Rap1GAP was an independent prognostic factor. Ectopic expression of Rap1GAP impaired cell migration and invasion, promoted the expression of E-cadherin and decreased the expression of MMP2. These results suggest that Rap1GAP functions as a novel suppressor of EMT and tumor metastasis in GC, and loss of Rap1GAP predicts poor prognosis in GC.
Rap1GAP是一种关键的肿瘤抑制因子，但其在胃癌（GC）中的作用鲜少被研究。在本研究中，我们发现Rap1GAP在GC中表达降低。Rap1GAP低表达与GC患者的pTNM晚期、Borrmann分型、肿瘤直径及不良预后呈正相关。Rap1GAP低表达与E-钙黏蛋白表达缺失及MMP2表达异常阳性相关。多因素分析表明，Rap1GAP低表达是一个独立的预后因素。Rap1GAP的异位表达损害细胞迁移和侵袭，促进E-钙黏蛋白表达并降低MMP2表达。这些结果表明，Rap1GAP在GC中作为上皮-间质转化和肿瘤转移的新型抑制因子发挥作用，Rap1GAP缺失预示GC患者预后不良。
