Cho Yong-Yeon
College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea.
Arch Pharm Res. 2017 Mar;40(3):291-303. doi: 10.1007/s12272-016-0880-z. Epub 2016 Dec 24.
RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation. RSKs respond to many growth factors, hormones, neurotransmitters and environmental stresses. In signaling cascades, RSK2 is regulated under the control of extracellular signal-regulated kinase 1 (ERK1) and 2 (ERK2) activities and is positioned upstream of transcription and epigenetic factors involved in cell proliferation, cell transformation and cancer development, as well as some kinases that modulate cell cycle progression. Over the last decade, our research group has studied the etiological roles of RSK2 in human cancer development, discovering that RSK2 plays a key role in cell proliferation, transformation and cancer development in humans. Based on our research, we concluded that RSK2 plays a key role as an onco-kinase by combinational protein-protein interaction with different binding partners depending on the cellular context. In this review, we discuss the function of the RSK2 signaling axis by interactions with binding partners in cancer development.
RSK2是一种丝氨酸/苏氨酸激酶，属于p90核糖体S6激酶（p90；RSKs）家族成员，该家族可调节由肿瘤启动子如表皮生长因子（EGF）、12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）和紫外线（UV）辐射诱导的细胞增殖和转化。RSKs对多种生长因子、激素、神经递质和环境应激作出反应。在信号级联反应中，RSK2受细胞外信号调节激酶1（ERK1）和2（ERK2）活性的调控，并位于参与细胞增殖、细胞转化和癌症发展的转录和表观遗传因子以及一些调节细胞周期进程的激酶的上游。在过去十年中，我们的研究小组研究了RSK2在人类癌症发展中的病因学作用，发现RSK2在人类细胞增殖、转化和癌症发展中起关键作用。基于我们的研究，我们得出结论，根据细胞环境，RSK2通过与不同结合伙伴的组合蛋白 - 蛋白相互作用作为一种癌激酶发挥关键作用。在本综述中，我们通过与癌症发展中结合伙伴的相互作用来讨论RSK2信号轴的功能。
