Moosazadeh Mahmood, Asemi Zatollah, Lankarani Kamran B, Tabrizi Reza, Maharlouei Najmeh, Naghibzadeh-Tahami Ahmad, Yousefzadeh Gholamreza, Sadeghi Reza, Khatibi Seyed Reza, Afshari Mahdi, Khodadost Mahmoud, Akbari Maryam
Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S99-S104. doi: 10.1016/j.dsx.2016.12.016. Epub 2016 Dec 13.
Gestational diabetes is the most prevalent metabolic disorder being firstly diagnosed during pregnancy. The relationship between the family history of diabetes and the gestational diabetes mellitus (GDM) has been investigated in several primary studies with a number of contradictions in the results. Hence, the purpose of the present study is to determine the relationship between the GDM and the family history of diabetes using the meta-analysis method.
All published papers in main national and international databases were systematically searched with some specific keywords to find the related studies between 2000 and 2016. We calculated the odds ratio (OR) with 95% confidence interval (CI) in analysis for each study using a random-effect and Mantel-Haenzel method. We also determined heterogeneity among these 33 articles and their publication bias.
We entered 33 relevant studies of 2516 articles into the meta-analysis process including 2697 women with family history of diabetes mellitus as well as 29134 women without. Of them, 954 and 4372 subjects developed GDM respectively. Combining the results of the primary studies using the meta-analysis method, the overall odds ratio of family history for developing GDM was estimated as of 3.46 (95% CI: 2.80-4.27).
This meta-analysis study revealed that the family history of diabetes is an important risk factor for the gestational diabetes mellitus.
妊娠期糖尿病是孕期首次诊断出的最常见的代谢紊乱疾病。一些初步研究调查了糖尿病家族史与妊娠期糖尿病（GDM）之间的关系，但结果存在诸多矛盾之处。因此，本研究旨在采用荟萃分析方法确定GDM与糖尿病家族史之间的关系。
通过一些特定关键词系统检索主要国家和国际数据库中所有已发表的论文，以查找2000年至2016年期间的相关研究。我们在每项研究的分析中使用随机效应和Mantel-Haenzel方法计算优势比（OR）及其95%置信区间（CI）。我们还确定了这33篇文章之间的异质性及其发表偏倚。
我们将2516篇文章中的33项相关研究纳入荟萃分析过程，其中包括2697名有糖尿病家族史的女性以及29134名无糖尿病家族史的女性。其中，分别有954名和4372名受试者患GDM。采用荟萃分析方法综合初步研究结果，患GDM的家族史总体优势比估计为3.46（95%CI：2.80 - 4.27）。
这项荟萃分析研究表明，糖尿病家族史是妊娠期糖尿病的一个重要危险因素。
