一名移植前患有肝脏炎性假瘤的患者成功进行干细胞移植

Successful Stem Cell Transplantation in a Patient with Pretransplant Hepatic Inflammatory Pseudotumour.

作者信息

de Mel Sanjay, Soe Zarni, Wong Benjamin, Ong Ching Ching, Teo Lynette, Tan Lip Kun

机构信息

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228.

Department of Pathology, National University Health System, 1E Kent Ridge Road, Singapore 119228.

出版信息

Case Rep Transplant. 2016;2016:6801916. doi: 10.1155/2016/6801916. Epub 2016 Nov 28.

DOI:10.1155/2016/6801916

PMID:28018703

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5149620/

Abstract

Inflammatory pseudotumours (IPT) are rare benign neoplasms of unknown aetiology. We present a case of hepatic IPT which was incidentally discovered in a patient with relapsed B-acute lymphoblastic leukaemia (B-ALL) undergoing pretransplant workup. After investigation to exclude an infective cause she underwent a reduced intensity conditioning stem cell transplant (SCT) successfully and currently remains well and in remission. On repeat liver MRI after SCT, the IPT was seen to be resolving. To the best of our knowledge this is the first report of an adult patient with hepatic IPT successfully undergoing SCT. The reduction in size of the IPT after SCT also suggests an inflammatory rather than an infective aetiology for IPT.

摘要

炎性假瘤（IPT）是病因不明的罕见良性肿瘤。我们报告一例肝IPT病例，该病例是在一名复发的B-急性淋巴细胞白血病（B-ALL）患者进行移植前检查时偶然发现的。在排除感染性病因的检查后，她成功接受了减低强度预处理干细胞移植（SCT），目前情况良好且处于缓解期。SCT后复查肝脏MRI时，发现IPT正在消退。据我们所知，这是首例成功接受SCT的成年肝IPT患者报告。SCT后IPT体积缩小也提示IPT的病因是炎症而非感染。