Steele J, Billington T, Janus E, Moran J
Department of Chemical Pathology, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
Atherosclerosis. 1989 Sep;79(1):47-50. doi: 10.1016/0021-9150(89)90032-4.
Comparison of lipid, lipoprotein and apolipoprotein levels was made between 3 groups: continuous ambulatory peritoneal dialysis patients (n = 5); haemodialysis patients (n = 15) and normals (n = 31). Continuous ambulatory peritoneal dialysis (CAPD) patients showed significantly elevated total cholesterol, low density lipoprotein (LDL)-cholesterol and apolipoprotein B (apo B) levels compared with haemodialysis and normal groups. Both CAPD and haemodialysis (HD) showed reduced levels of high density lipoprotein (HDL)-cholesterol and apolipoprotein A-I (apo A-I). Measurement of apo A-I and apo B in dialysate during a 6 h CAPD session indicated significant losses of apo A-I to dialysate with negligible losses of apo B. Grossly elevated apo B and reduced apo A-I indicates that CAPD patients are at increased risk of coronary heart disease and that their risk is probably greater than for haemodialysis patients.
对三组人群的脂质、脂蛋白和载脂蛋白水平进行了比较：持续性非卧床腹膜透析患者（n = 5）；血液透析患者（n = 15）和正常人（n = 31）。与血液透析组和正常组相比，持续性非卧床腹膜透析（CAPD）患者的总胆固醇、低密度脂蛋白（LDL）胆固醇和载脂蛋白B（apo B）水平显著升高。CAPD和血液透析（HD）患者的高密度脂蛋白（HDL）胆固醇和载脂蛋白A-I（apo A-I）水平均降低。在6小时的CAPD疗程中对透析液中的apo A-I和apo B进行测量，结果表明apo A-I大量流失到透析液中，而apo B的流失可忽略不计。apo B大幅升高和apo A-I降低表明CAPD患者患冠心病的风险增加，且其风险可能大于血液透析患者。
