Pellissier L P, Pujol C N, Becker J A J, Le Merrer J
Physiologie de la Reproduction et des Comportements, INRA UMR-0085, CNRS UMR-7247, INSERM, Université François Rabelais, IFCE, 37380, Nouzilly, France.
Département de Neurosciences, Institut de Génomique fonctionnelle, INSERM U-661, CNRS UMR-5203, 34094, Montpellier, France.
Handb Exp Pharmacol. 2018;247:227-260. doi: 10.1007/164_2016_89.
Delta opioid receptor (DOR) displays a unique, highly conserved, structure and an original pattern of distribution in the central nervous system, pointing to a distinct and specific functional role among opioid peptide receptors. Over the last 15 years, in vivo pharmacology and genetic models have allowed significant advances in the understanding of this role. In this review, we will focus on the involvement of DOR in modulating different types of hippocampal- and striatal-dependent learning processes as well as motor function, motivation, and reward. Remarkably, DOR seems to play a key role in balancing hippocampal and striatal functions, with major implications for the control of cognitive performance and motor function under healthy and pathological conditions.
δ阿片受体（DOR）在中枢神经系统中呈现出独特、高度保守的结构和原始的分布模式，表明其在阿片肽受体中具有独特且特定的功能作用。在过去15年里，体内药理学和遗传模型使我们对这一作用的理解取得了重大进展。在本综述中，我们将重点关注DOR在调节不同类型的海马体和纹状体依赖性学习过程以及运动功能、动机和奖赏方面的作用。值得注意的是，DOR似乎在平衡海马体和纹状体功能方面发挥着关键作用，这对健康和病理条件下认知表现和运动功能的控制具有重要意义。
