Nelson Shakira M, Batai Ken, Ahaghotu Chiledum, Agurs-Collins Tanya, Kittles Rick A
Cancer Prevention Fellow, Division of Cancer Prevention, National Cancer Institute, 9609 Medical Center Drive, Room 6E402, Bethesda, MD 20892, USA.
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 6E402, Bethesda, MD 20892, USA.
Nutrients. 2016 Dec 28;9(1):12. doi: 10.3390/nu9010012.
African American men have higher incidence rates of aggressive prostate cancer, where high levels of calcium and serum vitamin D deficient levels play a role in the racial differences in incidence. In this study, we examined associations of serum vitamin D with aggressive prostate cancer to improve our understanding of higher susceptibility of aggressive disease in this racial cohort. From Howard University Hospital, 155 African American men with clinically-identified prostate cancer were identified; 46 aggressive cases, and 58 non-aggressive cases. Serum vitamin D was assessed from fasting blood samples, and total calcium intake was assessed using the Block Food Frequency Questionnaire. Vitamin D receptor polymorphisms from three different loci were genotyped; , , and . Multivariate logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) comparing aggressive to non-aggressive prostate cancer. Vitamin D deficiency (<20 ng/mL) significantly increased risk of aggressive disease (OR: 3.1, 95% CI: 1.03-9.57, -value = 0.04). Stratification by total calcium showed high calcium levels (≥800 mg/day) modified this association (OR: 7.3, 95% CI: 2.15-47.68, -interaction = 0.03). Genetic variant appeared to increase the magnitude of association between deficient serum vitamin D and aggressive prostate cancer (OR: 3.64, 95% CI: 1.12-11.75, -value = 0.05). These findings suggest that high incidence of aggressive prostate cancer risk in African American men may be due in-part to deficient levels of serum vitamin D. Other factors, including genetics, should be considered for future studies.
非裔美国男性侵袭性前列腺癌的发病率较高，高钙水平和血清维生素D缺乏在发病率的种族差异中起作用。在本研究中，我们研究了血清维生素D与侵袭性前列腺癌的关联，以增进我们对该种族队列中侵袭性疾病易感性较高的理解。从霍华德大学医院确定了155名经临床诊断患有前列腺癌的非裔美国男性；其中46例为侵袭性病例，58例为非侵袭性病例。通过空腹血样评估血清维生素D，并使用Block食物频率问卷评估总钙摄入量。对来自三个不同位点的维生素D受体多态性进行基因分型； ， ，和 。使用多变量逻辑回归模型确定比较侵袭性前列腺癌与非侵袭性前列腺癌的比值比（OR）和95%置信区间（CI）。维生素D缺乏（<20 ng/mL）显著增加了侵袭性疾病的风险（OR：3.1，95%CI：1.03 - 9.57， -值 = 0.04）。按总钙分层显示，高钙水平（≥800 mg/天）改变了这种关联（OR：7.3，95%CI：2.15 - 47.68， -交互作用 = 0.03）。基因变异 似乎增加了血清维生素D缺乏与侵袭性前列腺癌之间关联的强度（OR：3.64，95%CI：1.12 - 11.75， -值 = 0.05）。这些发现表明，非裔美国男性侵袭性前列腺癌风险的高发病率可能部分归因于血清维生素D水平不足。未来的研究应考虑其他因素，包括遗传学。
