Neoplasma. 2017;64(2):283-288. doi: 10.4149/neo_2017_216.
L-type amino acid transporter 1 (LAT1) and CD98 are frequently expressed in various human cancers, and closely correlated with tumor aggressiveness and survival. However, little is known about the expression of LAT1 and CD98 in cutaneous angiosarcoma. The aim of this study is to investigate the clinicopathological significance of these markers in the dismal disease. A total of 52 patients with cutaneous angiosarcoma were retrospectively reviewed. Immunohistochemical staining of tumor specimens were evaluated using anti-LAT1, CD98 and Ki-67 antibodies. The rates of high expression for LAT1 and CD98 were 56% (29/52) and 79% (41/52), respectively. The frequency of high expression for CD98 was significantly higher than that for LAT1 (p=0.021). The low expression of CD98 was significantly associated with distant metastasis (p=0.044) and was identified as a significant prognostic predictor by multivariate analysis. The expression level of LAT1 was not significantly correlated with prognosis. The low expression of CD98 is a novel biomarker for predicting poor prognosis in patients with cutaneous angiosarcoma.
L 型氨基酸转运蛋白 1（LAT1）和 CD98 在各种人类癌症中经常表达，与肿瘤侵袭性和生存密切相关。然而，关于 LAT1 和 CD98 在皮肤血管肉瘤中的表达知之甚少。本研究旨在探讨这些标志物在这种恶性疾病中的临床病理意义。回顾性分析了 52 例皮肤血管肉瘤患者。使用抗 LAT1、CD98 和 Ki-67 抗体对肿瘤标本进行免疫组织化学染色。LAT1 和 CD98 的高表达率分别为 56%（29/52）和 79%（41/52）。CD98 的高表达频率明显高于 LAT1（p=0.021）。CD98 的低表达与远处转移显著相关（p=0.044），并通过多因素分析被确定为显著的预后预测因子。LAT1 的表达水平与预后无显著相关性。CD98 的低表达是预测皮肤血管肉瘤患者预后不良的一个新的生物标志物。
