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一项关于外周样本基因表达的研究数据集,以确定过敏性和非过敏性哮喘严重程度的生物标志物。

Data set on a study of gene expression in peripheral samples to identify biomarkers of severity of allergic and nonallergic asthma.

作者信息

Baos Selene, Calzada David, Cremades Lucía, Sastre Joaquín, Quiralte Joaquín, Florido Fernando, Lahoz Carlos, Cárdaba Blanca

机构信息

Immunology Department, IIS- Jiménez Díaz Foundation, UAM, Madrid, Spain; CIBERES, CIBER of Respiratory Diseases, Spain.

Immunology Department, IIS- Jiménez Díaz Foundation, UAM, Madrid, Spain.

出版信息

Data Brief. 2016 Dec 22;10:505-510. doi: 10.1016/j.dib.2016.12.035. eCollection 2017 Feb.

Abstract

This article contains information related to the research article entitled "Biomarkers associated with disease severity in allergic and nonallergic asthma" (S. Baos, D. Calzada, L. Cremades, J. Sastre, J. Quiralte, F. Florido, C. Lahoz, B. Cárdaba, In press). Specifically, the clinical criteria stablished for selecting the study population (=104 subjects) are described. Moreover, this article describes the criteria for selecting the 94 genes to be analyzed in PBMCs (peripheral blood mononuclear cells), it is provided a description of these genes and a Table with the genes most differentially expressed by clinical phenotypes and, finally it is detailed the experimental methodology followed for studying the protein expression of MSR1 (macrophage scavenger receptor 1), one of the genes evaluated in the research.

摘要

本文包含与题为《过敏性和非过敏性哮喘中与疾病严重程度相关的生物标志物》(S. 鲍斯、D. 卡尔扎达、L. 克雷马德斯、J. 萨斯特雷、J. 基拉尔泰、F. 弗洛里多、C. 拉霍斯、B. 卡尔达巴,即将发表)的研究文章相关的信息。具体而言,描述了为选择研究人群(=104名受试者)所确立的临床标准。此外,本文描述了选择要在PBMCs(外周血单核细胞)中分析的94个基因的标准,提供了这些基因的描述以及按临床表型差异表达最明显的基因列表,最后详细说明了研究MSR1(巨噬细胞清道夫受体1)蛋白表达所采用的实验方法,MSR1是该研究中评估的基因之一。

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