Jensen Lars Jørn, Nielsen Morten Schak, Salomonsson Max, Sørensen Charlotte Mehlin
a Departments of Veterinary Clinical and Animal Sciences , University of Copenhagen , Copenhagen , Denmark.
b Department of Biomedical Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
Channels (Austin). 2017 May 4;11(3):183-195. doi: 10.1080/19336950.2016.1273997. Epub 2017 Jan 5.
L-type voltage gated Ca channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mmHg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca channels (Ca3.1 and Ca3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca channels in autoregulation and vascular function.
L型电压门控钙通道被认为是肌源性反应期间钙内流的主要来源。然而，许多血管床也表达T型电压门控钙通道。最近的研究表明，这些通道可能在自身调节中也发挥作用。在低压（40 - 80毫米汞柱）下，T型通道影响脑和肠系膜血管床的肌源性反应。T型通道似乎也参与骨骼肌的自身调节。这篇综述讨论了T型电压门控钙通道在几种不同血管床自身调节中的表达和作用。缺乏特异性药理抑制剂一直是该领域的巨大挑战。现在，诸如缺乏T型电压门控钙通道（Ca3.1和Ca3.2）表达的小鼠等基因改造模型加强了这一研究。有望这些新工具将有助于进一步阐明电压门控T型钙通道在自身调节和血管功能中的作用。
