Chiao C H
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1989 Mar;11(2):92-4.
The effect of riboflavin deficiency and simultaneously, nitrosodimethylamine given by gastric intubation on the glutathione content of rat liver is reported. On different days of the experiments, glutathione content in the riboflavin deficient rat liver decreased to 55-61% of the controls. When nitrosodimethylamine was given by gastric intubation, glutathione content decreased markedly to 39-43% of the controls. The hepatic glutathione content of riboflavin deficient rats recovered to the level of the controls by supplying riboflavin. The alteration of rat hepatic glutathione content during riboflavin deficiency may imply as one of the promoting effects of riboflavin deficiency on the carcinogenesis of nitrosamines.
报道了核黄素缺乏以及同时经胃管给予二甲基亚硝胺对大鼠肝脏谷胱甘肽含量的影响。在实验的不同天数，核黄素缺乏的大鼠肝脏中的谷胱甘肽含量降至对照组的55 - 61%。当经胃管给予二甲基亚硝胺时，谷胱甘肽含量显著降至对照组的39 - 43%。通过补充核黄素，核黄素缺乏大鼠的肝脏谷胱甘肽含量恢复到对照组水平。核黄素缺乏期间大鼠肝脏谷胱甘肽含量的改变可能意味着核黄素缺乏对亚硝胺致癌作用的促进作用之一。
