Verdoux Helene, Devouche Emmanuel, Tournaire Michel, Levadou Anne
Univ. Bordeaux, U1219, F-33000, Bordeaux, France.
INSERM, U1219, F-33000, Bordeaux, France.
Arch Womens Ment Health. 2017 Jun;20(3):389-395. doi: 10.1007/s00737-016-0711-8. Epub 2017 Jan 7.
To explore whether prenatal exposure to diethylstilbestrol (DES) is associated with increased risk of poor psychological outcome independently of the occurrence of major somatic complications related to DES exposure. Data on health outcome were collected in women prenatally exposed to DES (n = 2566) and unexposed women (n = 2967) recruited in a French national survey. Women prenatally exposed to DES were 1.7 times more likely to have consulted a mental health specialist compared to unexposed women (adjusted odds ratio = 1.69, 95% confidence interval 1.47-1.96), independently of demographic characteristics, poor gynecological or obstetrical outcome, or history of cancer. Frequency of consultation with a mental health specialist in persons with a history of gynecological complications or cancer was comparable in women prenatally exposed to DES and unexposed women. Findings regarding psychological outcome obtained in the high-risk group of women prenatally exposed to DES may contribute to improving identification of psychological needs of all women presenting with gynecological abnormalities.
探讨产前暴露于己烯雌酚（DES）是否会独立于与DES暴露相关的主要躯体并发症的发生，而增加心理不良结局的风险。在一项法国全国性调查中，收集了产前暴露于DES的女性（n = 2566）和未暴露女性（n = 2967）的健康结局数据。与未暴露女性相比，产前暴露于DES的女性咨询心理健康专家的可能性高出1.7倍（调整后的优势比 = 1.69，95%置信区间1.47 - 1.96），这与人口统计学特征、不良的妇科或产科结局或癌症病史无关。有妇科并发症或癌症病史的人群中，产前暴露于DES的女性和未暴露女性咨询心理健康专家的频率相当。在产前暴露于DES的高危女性群体中获得的关于心理结局的研究结果，可能有助于改善对所有存在妇科异常的女性心理需求的识别。
