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治疗后低风险饮酒作为酒精使用障碍患者未来饮酒及问题后果的预测指标:一项9年随访研究

Posttreatment Low-Risk Drinking as a Predictor of Future Drinking and Problem Outcomes Among Individuals with Alcohol Use Disorders: A 9-Year Follow-Up.

作者信息

Kline-Simon Andrea H, Litten Raye Z, Weisner Constance M, Falk Daniel E

机构信息

Division of Research, Kaiser Permanente Northern California, Oakland, California.

National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.

出版信息

Alcohol Clin Exp Res. 2017 Mar;41(3):653-658. doi: 10.1111/acer.13334. Epub 2017 Feb 7.

Abstract

BACKGROUND

Treatment for alcohol use disorders (AUDs) has traditionally been abstinence oriented, but new research and regulatory guidelines suggest that low-risk drinking may also be an acceptable treatment outcome. However, little is known about long-term outcomes for patients who become low-risk drinkers posttreatment. This study explores a posttreatment low-risk drinking outcome as a predictor of future drinking and psychosocial outcomes over 9 years.

METHODS

Study participants were adults with AUDs at treatment entry who received follow-up interviews 6 months posttreatment intake (N = 1,061) in 2 large randomized studies conducted at Kaiser Permanente Northern California, a large private, nonprofit, integrated health system. Six-month drinking status was defined as abstinent, low-risk (nonabstinent, no 5+ drinking days), or heavy drinking (1 or more days of 5+ drinks). Using logistic regression models, we explored the relationship between past 30-day drinking status at 6 months and odds of being abstinent or a low-risk drinker (compared to heavy drinking), and positive Addiction Severity Index psychosocial outcomes over 9 years (9-year follow-up rate of 73%).

RESULTS

Abstainers and low-risk drinkers at 6 months had higher odds of recent abstinence/low-risk drinking over 9 years than heavy drinkers; abstainers had better drinking outcomes than low-risk drinkers. Additionally, among those with interview data, 95% of abstainers and 94% of low-risk drinkers at 6 months were abstinent/low-risk drinkers at 9 years; surprisingly, 89% of heavy drinkers at 6 months were also abstinent/low-risk drinkers although still significantly fewer than the other groups. Abstainers and low-risk drinkers at 6 months had better psychiatric outcomes, and abstainers had better family/social outcomes than heavy drinkers; medical outcomes did not differ. Low-risk drinkers and abstainers showed no reliable differences across psychosocial measures.

CONCLUSIONS

The findings suggest that a low-risk drinking outcome may be reasonable over the long-term for some alcohol-dependent individuals receiving addiction treatment.

摘要

背景

酒精使用障碍(AUDs)的治疗传统上以戒酒为导向,但新的研究和监管指南表明,低风险饮酒也可能是可接受的治疗结果。然而,对于治疗后成为低风险饮酒者的患者的长期结果知之甚少。本研究探讨治疗后低风险饮酒结果作为未来9年饮酒及心理社会结果预测指标的情况。

方法

研究参与者为入组治疗时患有酒精使用障碍的成年人,在北加利福尼亚凯撒医疗集团(一个大型私立非营利性综合医疗系统)进行的两项大型随机研究中,他们在治疗摄入后6个月接受了随访访谈(N = 1,061)。6个月时的饮酒状态定义为戒酒、低风险(非戒酒,无5天及以上饮酒日)或重度饮酒(1天及以上有5杯及以上饮酒量)。使用逻辑回归模型,我们探讨了6个月时过去30天饮酒状态与戒酒或成为低风险饮酒者(与重度饮酒相比)的几率之间的关系,以及9年期间成瘾严重程度指数心理社会结果为阳性的情况(9年随访率为73%)。

结果

6个月时的戒酒者和低风险饮酒者在9年期间近期戒酒/低风险饮酒的几率高于重度饮酒者;戒酒者的饮酒结果优于低风险饮酒者。此外,在有访谈数据的人群中,6个月时95%的戒酒者和94%的低风险饮酒者在9年时为戒酒者/低风险饮酒者;令人惊讶的是,6个月时89%的重度饮酒者也是戒酒者/低风险饮酒者,尽管仍明显少于其他组。6个月时的戒酒者和低风险饮酒者有更好的精神科结果,戒酒者的家庭/社会结果优于重度饮酒者;医疗结果无差异。低风险饮酒者和戒酒者在心理社会指标上没有可靠的差异。

结论

研究结果表明,对于一些接受成瘾治疗的酒精依赖个体,低风险饮酒结果从长期来看可能是合理的。

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