Tang Chunlin, Fang Kejing, Guo Yanli, Li Rui, Fan Xiaozhou, Chen Ping, Chen Zhaohui, Liu Qiangwei, Zou Ye
Department of Ultrasound, Southwest Hospital, Third Military Medical University, Chongqing, China.
J Ultrasound Med. 2017 Mar;36(3):531-538. doi: 10.7863/ultra.15.11075. Epub 2017 Jan 10.
The purpose of this study was to investigate the safety of the sulfur hexafluoride microbubble contrast agent SonoVue (Bracco SpA, Milan, Italy) and to implement precautions with the intent of further improving the safety of this contrast agent.
A total of 30,222 patients undergoing contrast-enhanced sonography of abdominal and superficial organs in our hospital from January 2005 to December 2014 were retrospectively investigated. SonoVue was used as the ultrasound contrast agent. The symptoms and treatments of adverse reactions occurring during the contrast-enhanced sonographic examinations were reviewed and analyzed.
No patient died as a result of any adverse reaction. Six patients (0.020%) had adverse reactions of varying degrees, including 2 patients (0.007%) who had signs of early anaphylactic shock (chest tightness, palpitations, sweating, and rapid and weak pulse, followed by cyanosis, a disappearing pulse, and a drop in blood pressure) that improved after active rescue. The remaining 4 patients developed the following: redness and a rash on the arm above the injection site, nasal bleeding and nausea, nausea and vomiting, and back pain with numbness of the lips and limbs. Symptoms in these 4 patients self-resolved after a period of rest.
Contrast-enhanced sonography with sulfur hexafluoride microbubbles had good clinical safety, but rare adverse reactions were observed. A comprehensive emergency plan and rescue measures for adverse reactions should be prepared and made available to minimize the occurrence of negative clinical outcomes.
本研究旨在调查六氟化硫微泡造影剂声诺维（意大利米兰百胜公司）的安全性，并采取预防措施以进一步提高该造影剂的安全性。
回顾性调查了2005年1月至2014年12月在我院接受腹部和浅表器官超声造影检查的30222例患者。使用声诺维作为超声造影剂。对超声造影检查过程中发生的不良反应的症状及处理情况进行回顾分析。
无患者因任何不良反应死亡。6例患者（0.020%）出现不同程度的不良反应，其中2例患者（0.007%）出现早期过敏性休克体征（胸闷、心悸、出汗、脉搏快速微弱，随后出现发绀、脉搏消失和血压下降），经积极抢救后好转。其余4例患者出现以下情况：注射部位上方手臂发红、皮疹，鼻出血伴恶心，恶心呕吐，背痛伴嘴唇及四肢麻木。这4例患者的症状经一段时间休息后自行缓解。
六氟化硫微泡超声造影具有良好的临床安全性，但仍观察到罕见的不良反应。应制定全面的不良反应应急预案及抢救措施，以尽量减少不良临床结局的发生。
