Gödecke Axel, Haendeler Judith
1 Medical Faculty, Institute for Cardiovascular Physiology, University of Duesseldorf , Duesseldorf, Germany .
2 Medical Faculty, Central Institute of Clinical Chemistry and Laboratory Medicine, University of Duesseldorf , Duesseldorf, Germany .
Antioxid Redox Signal. 2017 Apr 20;26(12):613-615. doi: 10.1089/ars.2017.6988. Epub 2017 Feb 7.
Intraorgan communication in the cardiovascular system is exerted not only by direct cell-cell contacts but also by locally released factors, which modulate neighboring cells by paracrine signals (e.g., NO, vascular endothelial growth factor, adenosine, reactive oxygen species). Moreover, cells in close proximity to the typical cardiovascular cells such as fibroblasts, red blood cells, as well as resident and invading immune cells must be considered in attempts to understand cardiovascular function in physiology and pathology. The second level of communication is the interorgan communication, which may be distinguished from intraorgan communication, since it involves signaling from remote organs to the heart and circulation. Therefore, mediators released by, for example, the kidney or skeletal muscle reach the heart and modulate its function. This is not only the case under physiological conditions, because there is increasing evidence that the organ-specific response to a primary insult may affect also the function of remote organs by the release of factors. This Forum will summarize novel mechanisms involved in intraorgan and interorgan communication of the cardiovascular system, with a special view on the remote organs, skeletal muscle and kidney. Antioxid. Redox Signal. 26, 613-615.
心血管系统中的器官内通讯不仅通过直接的细胞间接触来实现，还通过局部释放的因子来实现，这些因子通过旁分泌信号（如一氧化氮、血管内皮生长因子、腺苷、活性氧）调节邻近细胞。此外，在试图理解心血管系统在生理和病理状态下的功能时，必须考虑与典型心血管细胞（如成纤维细胞、红细胞以及驻留和浸润的免疫细胞）紧密相邻的细胞。通讯的第二个层面是器官间通讯，它可能与器官内通讯有所不同，因为它涉及从远处器官向心脏和循环系统的信号传递。因此，例如由肾脏或骨骼肌释放的介质会到达心脏并调节其功能。不仅在生理条件下是这样，因为越来越多的证据表明，对原发性损伤的器官特异性反应也可能通过因子的释放影响远处器官的功能。本论坛将总结心血管系统器官内和器官间通讯所涉及的新机制，特别关注远处器官、骨骼肌和肾脏。《抗氧化与氧化还原信号》26卷，613 - 615页 。
