Hayes Peran, Solon Jérôme
Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
Mech Dev. 2017 Apr;144(Pt A):2-10. doi: 10.1016/j.mod.2016.12.005. Epub 2017 Jan 7.
Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it has been extensively studied in the last twenty years. The process requires the coordination of several force generating mechanisms, that together will zip shut the epidermis. Recent works have provided a precise description of the cellular behavior at the origin of these forces and proposed quantitative models of the process. In this review, we will describe the different forces acting in dorsal closure. We will present our current knowledge on the mechanisms generating and regulating these forces and report on the different quantitative mathematical models proposed so far.
背侧闭合是胚胎发育后期的一个过程，包括封闭果蝇胚胎背侧的表皮间隙。由于其与人类伤口愈合和神经管闭合相似，在过去二十年中得到了广泛研究。该过程需要几种产生力的机制协同作用，共同拉合表皮。最近的研究工作对这些力产生的细胞行为进行了精确描述，并提出了该过程的定量模型。在这篇综述中，我们将描述背侧闭合过程中起作用的不同力量。我们将介绍目前关于这些力量产生和调节机制的知识，并报告迄今为止提出的不同定量数学模型。
