a Key Laboratory for Food Microbial Technology of Zhejiang Province , School of Food Science and Biotechnology, Zhejiang Gongshang University , Hangzhou , China.
Crit Rev Food Sci Nutr. 2018 Jun 13;58(9):1512-1525. doi: 10.1080/10408398.2016.1269719. Epub 2017 Jun 2.
Food allergy is a serious disease worldwide; it can significantly lower the standard of living of affected individuals and may be life-threatening. In particular, hypersensitivity to seafood has been increasing in recent years owing to rising consumption. The mucosal immune system plays a critical role in the onset of seafood allergy and other allergic diseases. Recently, experimental and clinical evidence has shown that probiotics significantly modulate immune responses and thus suppress allergic reactions. Therefore, in this review, we summarized the basic knowledge of seafood allergy, the mucosal immune system, and probiotic activities. We also reviewed the critical immune factors involved in allergic reactions, as well as the potential mechanism and the potential use of probiotics to ameliorate seafood allergy. The elucidation of these topics may help us to develop preventive and therapeutic approaches for seafood allergy and other immune disorders in the future.
食物过敏是一种全球性的严重疾病；它会显著降低受影响个体的生活质量，甚至可能危及生命。特别是，由于海鲜消费的增加，近年来对海鲜的过敏反应也在不断增加。黏膜免疫系统在海鲜过敏和其他过敏性疾病的发病中起着关键作用。最近，实验和临床证据表明，益生菌可显著调节免疫反应，从而抑制过敏反应。因此，在这篇综述中，我们总结了海鲜过敏、黏膜免疫系统和益生菌活性的基本知识。我们还回顾了过敏反应涉及的关键免疫因素，以及益生菌改善海鲜过敏的潜在机制和用途。阐明这些问题可能有助于我们未来开发预防和治疗海鲜过敏及其他免疫紊乱的方法。
