自噬在慢性肾脏病中的研究进展
Advance of autophagy in chronic kidney diseases.
作者信息
Deng Xu, Xie Yifan, Zhang Aihua
机构信息
a Department of Nephrology , Children's Hospital of Nanjing Medical University , Nanjing , China.
b Jiangsu Key Laboratory of Pediatrics , Nanjing Medical University , Nanjing , China.
出版信息
Ren Fail. 2017 Nov;39(1):306-313. doi: 10.1080/0886022X.2016.1274662.
Abstract
Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues and experimental animal models implicate that autophagy regulation is the critical aspects in chronic kidney diseases (CKD). Here, we summarize the current studies on the role of autophagy in CKD. Unveiling the precise regulation mechanism of autophagy in CKD is essential for developing potential prevention, diagnostic and therapeutic targets of these sticky clinical challenges.
摘要
自噬是一种高度保守的细胞存活机制，在许多生物学过程和疾病状态中成为一条重要途径。对培养的肾细胞、人类肾脏组织和实验动物模型的研究表明，自噬调节是慢性肾脏病（CKD）的关键方面。在此，我们总结了目前关于自噬在CKD中作用的研究。揭示CKD中自噬的精确调节机制对于开发应对这些棘手临床挑战的潜在预防、诊断和治疗靶点至关重要。
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