自噬在慢性肾脏病中的研究进展
Advance of autophagy in chronic kidney diseases.
作者信息
Deng Xu, Xie Yifan, Zhang Aihua
机构信息
a Department of Nephrology , Children's Hospital of Nanjing Medical University , Nanjing , China.
b Jiangsu Key Laboratory of Pediatrics , Nanjing Medical University , Nanjing , China.
出版信息
Ren Fail. 2017 Nov;39(1):306-313. doi: 10.1080/0886022X.2016.1274662.
Abstract
Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues and experimental animal models implicate that autophagy regulation is the critical aspects in chronic kidney diseases (CKD). Here, we summarize the current studies on the role of autophagy in CKD. Unveiling the precise regulation mechanism of autophagy in CKD is essential for developing potential prevention, diagnostic and therapeutic targets of these sticky clinical challenges.
摘要
自噬是一种高度保守的细胞存活机制，在许多生物学过程和疾病状态中成为一条重要途径。对培养的肾细胞、人类肾脏组织和实验动物模型的研究表明，自噬调节是慢性肾脏病（CKD）的关键方面。在此，我们总结了目前关于自噬在CKD中作用的研究。揭示CKD中自噬的精确调节机制对于开发应对这些棘手临床挑战的潜在预防、诊断和治疗靶点至关重要。
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本文引用的文献
1
Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis.
Autophagy. 2016 Sep;12(9):1472-86. doi: 10.1080/15548627.2016.1190071. Epub 2016 Jun 15.
2
Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction.
Autophagy. 2016 Jun 2;12(6):976-98. doi: 10.1080/15548627.2016.1166317. Epub 2016 Apr 28.
3
Reactive oxygen species-initiated autophagy opposes aldosterone-induced podocyte injury.
Am J Physiol Renal Physiol. 2016 Apr 1;310(7):F669-F678. doi: 10.1152/ajprenal.00409.2015. Epub 2016 Jan 13.
4
The roles of oxidative stress, endoplasmic reticulum stress, and autophagy in aldosterone/mineralocorticoid receptor-induced podocyte injury.
Lab Invest. 2015 Dec;95(12):1374-86. doi: 10.1038/labinvest.2015.118. Epub 2015 Sep 28.
5
Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in human non-small cell lung cancer cells.
Biochem Biophys Res Commun. 2015 Sep 11;465(1):64-70. doi: 10.1016/j.bbrc.2015.07.130. Epub 2015 Jul 30.
6
Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review.
Nephrol Dial Transplant. 2015 Aug;30 Suppl 4(Suppl 4):iv6-16. doi: 10.1093/ndt/gfv131.
7
(Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose.
Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E302-10. doi: 10.1152/ajpendo.00603.2014. Epub 2015 Jun 16.
8
Oxidative stress in chronic kidney disease.
Iran J Kidney Dis. 2015 May;9(3):165-79.
9
Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.
PLoS One. 2015 Feb 17;10(2):e0117400. doi: 10.1371/journal.pone.0117400. eCollection 2015.
10
Oxidative stress and autophagy: crucial modulators of kidney injury.
Redox Biol. 2015;4:208-14. doi: 10.1016/j.redox.2015.01.001. Epub 2015 Jan 13.
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