Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.
Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.
Kidney Int. 2017 Feb;91(2):270-272. doi: 10.1016/j.kint.2016.11.009.
Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity.
脂肪组织一直被认为能分泌各种内分泌因子。新出现的证据表明，脂肪细胞因子通过涉及白细胞介素-6、瘦素的内分泌环在调节全身矿物质稳态方面发挥作用，现在还包括脂联素，所有这些都与 FGF23 和维生素 D 相互作用，从而改变肾脏对钙和磷代谢的控制。了解这些调节环可能有助于阐明控制矿物质稳态及其在与肥胖相关疾病中失调的复杂器官间串扰。
