破冰之旅：髓质海绵肾疾病的尿蛋白质组学。
Breaking the ice: urine proteomics of medullary sponge kidney disease.
机构信息
Pediatric Translational Research Unit, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.
出版信息
Kidney Int. 2017 Feb;91(2):281-283. doi: 10.1016/j.kint.2016.10.032.
Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinically compatible enzyme-linked immunosorbent assay. The neglected issue of stone pathogenesis was also evidenced. This commentary discusses several considerations in biomarker validation, and how urinary proteomics breaks new ground in MSK research.
尿蛋白质组学是一种很有前途的生物标志物研究工具，特别是在复杂的肾脏疾病中。Fabris 及其同事使用无标记定量蛋白质组学平台和临床兼容的酶联免疫吸附测定法报告说，尿层粘连蛋白亚单位α-2 是髓质海绵肾 (MSK) 疾病的潜在诊断标志物。同时也证明了被忽视的结石发病机制问题。本文讨论了生物标志物验证中的几个注意事项，以及尿蛋白质组学在 MSK 研究中的新突破。
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