针对不可分型流感嗜血杆菌的候选疫苗：综述
Vaccine Candidates against Nontypeable Haemophilus influenzae: a Review.
作者信息
Behrouzi Ava, Vaziri Farzam, Rahimi-Jamnani Fatemeh, Afrough Parviz, Rahbar Mohammad, Satarian Fereshteh, Siadat Seyed Davar
机构信息
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.
出版信息
Iran Biomed J. 2017 Mar;21(2):69-76. doi: 10.18869/acadpub.ibj.21.2.69. Epub 2017 Mar 1.
Abstract
Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic diseases such as chronic bronchitis and chronic obstructive pulmonary disease in the lower respiratory tract of adults. Such bacteria express several outer membrane proteins, some of which have been studied as candidates for vaccine development. Due to the lack of effective vaccines as well as the spread and prevalence of NTHi worldwide, there is an urgent need to design and develop effective vaccine candidates against these strains.
摘要
非包膜、不可分型的流感嗜血杆菌（NTHi）仍然是儿童和成人急性中耳炎及呼吸道疾病的重要病因。NTHi细菌是呼吸道感染的主要病因之一，包括急性中耳炎、囊性纤维化以及儿童社区获得性肺炎，在发展中国家尤为如此。该细菌还可导致成人下呼吸道的慢性疾病，如慢性支气管炎和慢性阻塞性肺疾病。此类细菌表达多种外膜蛋白，其中一些已作为疫苗开发候选物进行研究。由于缺乏有效的疫苗以及NTHi在全球的传播和流行，迫切需要设计和开发针对这些菌株的有效候选疫苗。
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