QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Trends Parasitol. 2017 May;33(5):400-413. doi: 10.1016/j.pt.2016.12.013. Epub 2017 Jan 11.
Protease inhibitors play crucial roles in parasite development and survival, counteracting the potentially damaging immune responses of their vertebrate hosts. However, limited information is currently available on protease inhibitors from schistosomes and food-borne trematodes. Future characterization of these molecules is important not only to expand knowledge on parasitic fluke biology but also to determine whether they represent novel vaccine and/or drug targets. Moreover, protease inhibitors from flukes may represent lead compounds for the development of a new range of therapeutic agents against inflammatory disorders and cancer. This review discusses already identified protease inhibitors of fluke origin, emphasizing their biological function and their possible future development as new intervention targets.
蛋白酶抑制剂在寄生虫的发育和生存中起着至关重要的作用，它们可以抵抗脊椎动物宿主潜在的有害免疫反应。然而，目前关于血吸虫和食源性吸虫的蛋白酶抑制剂的信息有限。这些分子的未来特征不仅对于扩展寄生吸虫生物学知识很重要，而且对于确定它们是否代表新的疫苗和/或药物靶点也很重要。此外，吸虫中的蛋白酶抑制剂可能代表了一类新的治疗炎症性疾病和癌症的治疗药物的先导化合物。本文综述了已鉴定的吸虫来源的蛋白酶抑制剂，强调了它们的生物学功能及其作为新的干预靶点的可能未来发展。
