Unilever R&D Bangalore, Bangalore, India.
Exp Dermatol. 2017 Sep;26(9):827-829. doi: 10.1111/exd.13285. Epub 2017 Apr 11.
Antimicrobial peptides (AMPs) form a part of the skin's innate immune system. Their primary activity is to provide antimicrobial benefits and hence protect from infections. AMPs that are present on human skin include psoriasin (S100A7), RNase 7, lysozyme, LL-37 and defensins. Niacinamide is a well-known cosmetic ingredient that has been used traditionally for multiple skin benefits. Recent data indicate that niacinamide treatment can boost AMPs in human gut epithelial cells and in neutrophils. Treatment with niacinamide in mice also provided protection from skin infections by enhancing AMPs. In this article, we find that treatment with niacinamide formulation provides long-lasting protection against bacteria, potentially through the activation of an AMP response.
抗菌肽 (AMPs) 是皮肤固有免疫系统的一部分。它们的主要作用是提供抗菌益处，从而防止感染。存在于人类皮肤上的 AMP 包括菌属素 (S100A7)、RNase 7、溶菌酶、LL-37 和防御素。烟酰胺是一种众所周知的化妆品成分，传统上用于多种皮肤益处。最近的数据表明，烟酰胺处理可以通过增强人类肠道上皮细胞和中性粒细胞中的 AMP 来促进 AMP。在小鼠中用烟酰胺处理也通过增强 AMP 提供了对皮肤感染的保护。在本文中，我们发现烟酰胺配方的处理提供了对细菌的持久保护，可能是通过 AMP 反应的激活。
