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成功治疗起初对常规治疗无效的严重巴氯芬中毒。

Successful treatment of severe baclofen toxicosis initially refractory to conventional treatment.

作者信息

Fox Christine M, Daly Meredith L

机构信息

Critical Care Department BluePearl Veterinary Partners New York City New York USA.

出版信息

Clin Case Rep. 2016 Dec 20;5(1):44-50. doi: 10.1002/ccr3.736. eCollection 2017 Jan.

Abstract

After ingesting a dose of baclofen thought to be lethal, a patient with severe neurologic signs was successfully managed despite initially being refractory to treatment. Patients with persistent neurologic abnormalities may still have an excellent prognosis despite lack of initial response. Additionally, we present a potential case of benzodiazepine withdrawal.

摘要

一名患者摄入了一剂被认为具有致死性的巴氯芬后,尽管最初对治疗无反应,但伴有严重神经体征的该患者最终成功得到救治。尽管最初没有反应,但持续性神经功能异常的患者仍可能预后良好。此外,我们还介绍了一例潜在的苯二氮䓬戒断病例。

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本文引用的文献

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Clinical applications of intravenous lipid emulsion therapy.静脉注射脂质乳剂疗法的临床应用。
J Anesth. 2015 Dec;29(6):920-6. doi: 10.1007/s00540-015-2036-6. Epub 2015 Jun 7.
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Baclofen toxicosis in dogs and cats: 145 cases (2004-2010).犬猫巴氯芬中毒:145例(2004 - 2010年)
J Am Vet Med Assoc. 2012 Oct 15;241(8):1059-64. doi: 10.2460/javma.241.8.1059.
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Baclofen overdose mimicking brain death.巴氯芬过量致脑死亡样表现。
Clin Toxicol (Phila). 2012 Feb;50(2):141-4. doi: 10.3109/15563650.2011.654209. Epub 2012 Jan 31.
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Treating baclofen overdose by hemodialysis.血液透析治疗巴氯芬中毒。
Am J Emerg Med. 2012 Oct;30(8):1654.e5-7. doi: 10.1016/j.ajem.2011.07.013. Epub 2011 Oct 24.
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The use of intravenous lipid emulsion as an antidote in veterinary toxicology.静脉注射脂质乳剂在兽医毒理学中作为解毒剂的应用。
J Vet Emerg Crit Care (San Antonio). 2011 Aug;21(4):309-20. doi: 10.1111/j.1476-4431.2011.00657.x. Epub 2011 Jun 30.
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Haemodialysis clearance of baclofen.巴氯芬的血液透析清除率
Eur J Clin Pharmacol. 2007 Dec;63(12):1143-6. doi: 10.1007/s00228-007-0371-8. Epub 2007 Sep 2.
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Baclofen overdose: defining the spectrum of toxicity.巴氯芬过量:界定毒性范围
Emerg Med Australas. 2006 Feb;18(1):77-82. doi: 10.1111/j.1742-6723.2006.00805.x.

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