Niwayama Risa, Nishitani Shota, Takamura Tsunehiko, Shinohara Kazuyuki, Honda Sumihisa, Miyamura Tsunetake, Nakao Yuko, Oishi Kazuyo, Araki-Nagahashi Miyuki
1 Unit of Nursing, Department of Reproductive Health, Graduate School of Biomedical Sciences, Nagasaki University , Nagasaki, Japan .
2 Unit of Basic Medical Sciences, Department of Neurobiology and Behavior, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University , Nagasaki, Japan .
Breastfeed Med. 2017 Mar;12:103-109. doi: 10.1089/bfm.2016.0052. Epub 2017 Jan 19.
The current study sought to characterize changes in salivary oxytocin (OT) secretion patterns across the breastfeeding cycle, and to evaluate whether breastfeeding has a positive effect on mood disturbances related to postpartum depression, via endogenous OT release.
Twenty-four primiparous mothers who delivered vaginally at term and were exclusively breastfeeding were examined 4-5 days postpartum. Salivary OT was measured using enzyme immunoassays at 30 minutes before breastfeeding (baseline), during breastfeeding (feeding), and 30 minutes after completing breastfeeding (postfeeding). In addition, maternal mood changes were evaluated at baseline and postfeeding using the Profile of Mood States (POMS) questionnaire.
OT levels rose significantly during feeding (p < .05) and postfeeding (p < 0.05), compared with baseline. POMS scores for Tension-Anxiety were decreased postfeeding compared with baseline (p < 0.001). This decrease was significantly associated with increased OT (feeding minus baseline: r = -0.52, r = -0.51, postfeeding minus baseline: r = -0.53, r = -0.52, ps < 0.05). POMS scores for Fatigue and Confusion also decreased, while Vigor significantly increased. Significant correlations were found between Fatigue decreases and OT increases (feeding minus baseline: r = -0.48, r = -0.53, postfeeding minus baseline: r = -0.60, ps < 0.05). This result partially contradicted with the finding of no correlation between increased Vigor and increased OT.
OT is released across the breastfeeding cycle and can be detected with salivary measurement. This OT release exhibited a temporary anxiolytic-like calming effect on postpartum maternal mood disturbances.
本研究旨在描述母乳喂养周期中唾液催产素（OT）分泌模式的变化，并评估母乳喂养是否通过内源性OT释放对与产后抑郁相关的情绪障碍产生积极影响。
对24名足月阴道分娩且纯母乳喂养的初产妇在产后4 - 5天进行检查。在母乳喂养前30分钟（基线）、母乳喂养期间（喂奶时）和完成母乳喂养后30分钟（喂奶后），使用酶免疫分析法测量唾液OT。此外，在基线和喂奶后使用情绪状态剖面图（POMS）问卷评估母亲的情绪变化。
与基线相比，喂奶时（p < 0.05）和喂奶后（p < 0.05）OT水平显著升高。与基线相比，喂奶后紧张 - 焦虑的POMS评分降低（p < 0.001）。这种降低与OT升高显著相关（喂奶时减去基线：r = -0.52，r = -0.51，喂奶后减去基线：r = -0.53，r = -0.52，p < 0.05）。疲劳和困惑的POMS评分也降低，而活力显著增加。在疲劳降低与OT升高之间发现显著相关性（喂奶时减去基线：r = -0.48，r = -0.53，喂奶后减去基线：r = -0.60，p < 0.05）。这一结果部分与活力增加和OT增加之间无相关性的发现相矛盾。
OT在整个母乳喂养周期中释放，并且可以通过唾液测量检测到。这种OT释放对产后母亲的情绪障碍表现出暂时的抗焦虑样平静作用。
