绝经后女性血清尿酸与高敏C反应蛋白的关联

Association of serum uric acid with high-sensitivity C-reactive protein in postmenopausal women.

作者信息

Raeisi A, Ostovar A, Vahdat K, Rezaei P, Darabi H, Moshtaghi D, Nabipour I

机构信息

a The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.

b The Persian Gulf Marine Biotechnology Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.

出版信息

Climacteric. 2017 Feb;20(1):44-48. doi: 10.1080/13697137.2016.1247261. Epub 2016 Oct 19.

DOI:10.1080/13697137.2016.1247261

PMID:28105870

Abstract

OBJECTIVES

To explore the independent correlation between serum uric acid and low-grade inflammation (measured by high-sensitivity C-reactive protein, hs-CRP) in postmenopausal women.

METHODS

A total of 378 healthy Iranian postmenopausal women were randomly selected in a population-based study. Circulating hs-CRP levels were measured by highly specific enzyme-linked immunosorbent assay method and an enzymatic calorimetric method was used to measure serum levels of uric acid. Pearson correlation coefficient, multiple linear regression and logistic regression models were used to analyze the association between uric acid and hs-CRP levels.

RESULTS

A statistically significant correlation was seen between serum levels of uric acid and log-transformed circulating hs-CRP (r = 0.25, p < 0.001). After adjustment for age and cardiovascular risk factors (according to NCEP ATP III criteria), circulating hs-CRP levels were significantly associated with serum uric acid levels (β = 0.20, p < 0.001). After adjustment for age and cardiovascular risk factors, hs-CRP levels ≥3 mg/l were significantly associated with higher uric acid levels (odds ratio =1.52, 95% confidence interval 1.18-1.96).

CONCLUSION

Higher serum uric acid levels were positively and independently associated with circulating hs-CRP in healthy postmenopausal women.

摘要

目的

探讨绝经后女性血清尿酸与低度炎症（通过高敏C反应蛋白，hs-CRP测定）之间的独立相关性。

方法

在一项基于人群的研究中，随机选取了378名健康的伊朗绝经后女性。采用高特异性酶联免疫吸附测定法测量循环hs-CRP水平，并用酶比色法测量血清尿酸水平。采用Pearson相关系数、多元线性回归和逻辑回归模型分析尿酸与hs-CRP水平之间的关联。

结果

血清尿酸水平与经对数转换的循环hs-CRP之间存在统计学显著相关性（r = 0.25，p < 0.001）。在调整年龄和心血管危险因素（根据NCEP ATP III标准）后，循环hs-CRP水平与血清尿酸水平显著相关（β = 0.20，p < 0.001）。在调整年龄和心血管危险因素后，hs-CRP水平≥3mg/l与较高的尿酸水平显著相关（比值比 = 1.52，95%置信区间1.18 - 1.96）。