Bobrov V A, Shchepotin Iu B, Sui'lkhi A
Kardiologiia. 1989 Jul;29(7):17-21.
Digoxin was studied for its effects on the function of sinus nodal automatism and atrioventricular conduction in an acute experiment and during a course therapy. Digoxin was shown to exert substantial effects on the sinus node with its retained function and dysfunction. When digoxin was given in a daily dose of 0.375 mg, there was an increase in sinoatrial conduction time. When the drug was administered in a single dose of 0.4 mg, there was no substantial change in the atrioventricular conduction. During its course therapy, digoxin failed to produce antirecurrent antiarrhythmic effects.
在一项急性实验和疗程治疗中，研究了地高辛对窦房结自律功能和房室传导功能的影响。结果显示，地高辛对功能正常和功能异常的窦房结均有显著作用。当每日给予地高辛0.375毫克时，窦房传导时间延长。当单次给予0.4毫克该药物时，房室传导没有显著变化。在疗程治疗期间，地高辛未能产生抗复发抗心律失常作用。
