[Effect of digoxin on sinoatrial node automatism and atrio-ventricular conductivity in patients with a paroxysmal form of atrial fibrillation].

Digoxin was studied for its effects on the function of sinus nodal automatism and atrioventricular conduction in an acute experiment and during a course therapy. Digoxin was shown to exert substantial effects on the sinus node with its retained function and dysfunction. When digoxin was given in a daily dose of 0.375 mg, there was an increase in sinoatrial conduction time. When the drug was administered in a single dose of 0.4 mg, there was no substantial change in the atrioventricular conduction. During its course therapy, digoxin failed to produce antirecurrent antiarrhythmic effects.